CDK5的表达与脑损伤时间推断的相关性研究进展  

Progress on Correlation between the Expression of CDK5 and Brain Injury Time

作　　者：马诗雨[1,2] 李如波[1] 罗宇家[1,2] 吕孟妍 王汉志[1] 王正印[1] 

机构地区：[1]中国医科大学法医学院法医病理学研究室,辽宁沈阳110001 [2]中国医科大学,辽宁沈阳110001

出　　处：《法医学杂志》2016年第1期58-60,共3页Journal of Forensic Medicine

基　　金：辽宁省教育厅科学研究一般项目(L2013317);辽宁省自然科学基金项目(2014021027)

摘　　要：细胞周期蛋白依赖激酶5(cyclin-dependent kinase 5,CDK5)是CDK家族中一类不直接调控细胞周期的蛋白。CDK5通过靶蛋白的磷酸化在神经细胞的发育、修复及退行性变等方面发挥着不可替代的作用。脑损伤是指暴力作用于头部造成的脑组织器质性损伤,由于损伤发生后机体启动应激及修复机制,脑组织中变化的多种蛋白及酶类物质可作为损伤时间判定的指标。本文就CDK5的分布、活性机制、生理作用及其脑损伤研究与其作为脑损伤标志物可能性的研究进展进行综述。Cyclin-dependent kinase 5 （CDK5） is a member of cyclin-dependent kinase family, which does not directly regulate cell cycle. Through phosphorylation of target protein, CDK5 plays an irreplace- able role in the development, reparation and degeneration of neurons. Brain injury refers to the organic injury of brain tissue caused by external force hit on the head. Owing to the stress and repair system activated by our body itself after injury, various proteins and enzymes of the brain tissues are changed quantitatively, which can be used as indicators for estimating the time of injury. This review summarizes the progress on the distribution, the activity mechanism and the physiological effects of CDK5 after brain injury and its corresponding potential served as a marker for brain injury determination.

关 键 词：法医病理学 脑损伤 综述[文献类型] 细胞周期蛋白依赖激酶5 损伤时间 

分 类 号：R329-33[医药卫生—人体解剖和组织胚胎学]