杆状病毒包埋型病毒粒子研究进展  

Research Advances in Baculovirus Occlusion-derived Virions

作　　者：朱士茂 李慧 

机构地区：[1]深圳市卫光生物制品股份有限公司,深圳市518107

出　　处：《病毒学报》2016年第1期93-100,共8页Chinese Journal of Virology

基　　金：深圳重组血浆蛋白类创新药物工程实验室项目

摘　　要：杆状病毒是一类专一性感染节肢动物的病原微生物,在其生活周期中产生两种不同形态的病毒粒子,即芽生型病毒粒子和包埋型病毒粒子。自然界中,杆状病毒通过经口感染的方式在其宿主的中肠中建立原发性感染,杆状病毒的包埋型病毒粒子在此过程中发挥关键作用。本文回顾了杆状病毒的基本特性,阐述杆状病毒包埋型病毒粒子的蛋白组成及分类,并着重介绍多粒包埋型病毒粒子的进化及在杆状病毒经口感染过程建立中的意义,对进一步了解杆状病毒的进化历程和侵染机制具有重要的指导意义。Baculoviruses are a family of arthropod-specific viruses that produce two morphologically distinct types of virions（budded and occlusion-derived）in their lifecycle.Baculoviruses establish infection in the midgut of their host via the oral route：occlusion-derived virions have pivotal roles in these processes.This review summarizes the basic characteristics of baculoviruses,and discusses the composition and classification of baculovirus occlusion-derived virions.The latter focuses mainly on the evolution and role of multiple occlusion-derived virions in the lifecycle of baculoviruses.These achievements should aid understanding the evolution and infection mechanisms of baculoviruses.

关 键 词：杆状病毒 昆虫中肠 多粒包埋型病毒粒子 经口感染 

分 类 号：R373.9[医药卫生—病原生物学]