进展期白癜风患者治疗后血清中sICAM-1、IFN-γ的变化  

Changes of Serum Soluble Intercellular Adhesion Molecule-1 and Interferon-γ after Treatment in Active Vitiligo Patients

作　　者：丁敏[1] 张建中[2] 杜鹃[2] 

机构地区：[1]江苏省徐州市中心医院,徐州221009 [2]北京大学人民医院,北京100044

出　　处：《中国中西医结合皮肤性病学杂志》2016年第1期34-36,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的探讨进展期白癜风患者治疗后血清中可溶性细胞间黏附分子-1(s ICAM-1)、干扰素-γ(IFN-γ)水平的变化及临床意义。方法收集33例进展期白癜风患者作为治疗组,采用酶联免疫吸附试验(ELISA)方法检测患者血清中sICAM-1、IFN-γ水平,并与20例稳定期白癜风患者及20例健康人对照;33例进展期白癜风患者均给予综合治疗,总疗程为16周,疗程结束后评定疗效并再次检测血清sICAM-1、IFN-γ水平。结果进展期白癜风患者血清s ICAM-1、IFN-γ平均水平明显高于稳定期白癜风患者及正常人,差异有统计学意义;稳定期白癜风患者血清sICAM-1、IFN-γ平均水平与正常人比较差异无统计学意义;治疗后进展期白癜风患者血清sICAM-1、IFN-γ平均水平较治疗前明显降低,差异有统计学意义;治疗有效组进展期白癜风患者治疗后血清sICAM-1、IFN-γ降低程度高于治疗无效组,差异有统计学意义。结论白癜风患者血清s ICAM-1、IFN-γ可反映疾病活动性,其水平变化可能与进展期白癜风的转归及临床疗效相关。Objective In order to investigate the changes and clinical significance of serum soluble intercellular adhesion molecule-1（sICAM-1） and interferon-γ（IFN-γ） in active vitiligo patients before and after treatments. Methods Thirty-three patients with active vitiligo were included in this study as treatment group.Enzyme-linked immnnosorbent assay （ELISA） was used to detect the levels of slCAM-1 and IFN-γ in serum, and then compared with 20 patients with stable vitiligo and 20 heahhy controls. Thirty-three patients with active vitiligo were received integrated therapy. Treatment regimens were performed for 16 weeks. Clinical efficacy was evaluated at the end of the study. The levels of slCAM-1 and IFN-γin serum were detected again. Results The expression of slCAM-1 and IFN-γ was higher in active vitiligo patients than in stable vitiligo patients as well as in healthy controls. There was no significant difference in the serum level of sICAM-1 and IFN-γ between patients with stable vitiligo and the healthy controls. After the treatment, the expression of slCAM -1 and IFN-γ was dec teased compared with that of before treatment. Among 33 patients, the variations of slCAM-I and IFN-γ after treatment was significantly bigger in those patients who responded successfully than in those patients who responded poorly. Conclusion The expression of slC AM-I and IFN-3, reflects the activity of vitiligo. The variations of serum levels of sICAM-I and IFN-γ have a correlation with the outcomes and efficacy in active vitiligo.

关 键 词：进展期白癜风 可溶性细胞间黏附分子-1 干扰素-Γ 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]