片仔癀对大肠杆菌内毒素致新西兰兔发热模型的解热抗炎作用  

Antipyretic and Anti-inflammatory Effects of Pien Tze Huang on Lipopolysaccharide Induced Febrile Response in Rabbits

作　　者：黄进明 洪绯 张泽修 郑海音[2] 洪振丰[2] 

机构地区：[1]漳州片仔癀药业股份有限公司,福建漳州363000 [2]福建中医药大学,福州350122

出　　处：《江西中医药大学学报》2016年第1期75-77,共3页Journal of Jiangxi University of Chinese Medicine

基　　金：福建省科技厅高校产学合作重大项目(2013Y4005)

摘　　要：目的:探讨片仔癀(PZH)对大肠杆菌内毒素(LPS)致新西兰兔发热模型的解热抗炎作用。方法:新西兰兔42只,雌雄各半,随机分为7组:正常对照组、模型组、阿司匹林对照组、小柴胡颗粒剂组、PZH0.24g/kg、0.12g/kg、0.06g/kg剂量组,观察灌胃给药不同剂量(0.24g/kg、0.12g/kg、0.06g/kg)的PZH后不同时间点的体温变化,同时观察PZH对兔血清TNF-α、IL-1β、IL-8、白细胞含量的影响。结果:LPS致新西兰兔发热模型中,小柴胡颗粒剂和片仔癀0.24g/kg、0.12g/kg、0.06g/kg剂量组与模型组比较有显著性差异(P<0.05),且片仔癀各给药组的体温的降低与药物呈剂量依赖效应。小柴胡颗粒剂和片仔癀0.24g/kg、0.12g/kg、0.06g/kg剂量组兔血清TNF-α、IL-1β、IL-8、白细胞含量与模型组比较有显著性差异(P<0.05),且片仔癀各给药组兔血清TNF-α、IL-1β、IL-8、白细胞含量的降低与药物呈剂量依赖效应。结论:片仔癀具有一定的解热抗炎作用,其作用与阿司匹林相当、优于小柴胡颗粒剂。Objective： To explore antipyretic and anti-inflammatory effects of Pien Tze Huang（ PZH） on lipopolysaccharide（ LPS） induced febrile response in rabbits. Methods： 42 rabbits（ half male and half female） were divided into normal group,model group,aspirin group,Xiaocaihu granule group,0. 24 g / kg dose of PZH group,0. 12 g / kg dose of PZH group and 0. 06 g / kg dose of PZH group.The fever model of rabbits was induced by injection of LPS to observe the effect of antipyretic and anti-inflammatory effects of PZH.Tempretures of different time were observed after administrating PZH（ 0. 24 g / kg,0. 12 g / kg and 0. 06 g / kg）. At the same time,the effect of PZH on levels of TNF-α,IL-1β,IL-8 and leukocyte were determined. Results： Compared with model group,Xiaocaihu granule group,0. 24 g / kg dose of PZH group,0. 12 g / kg dose of PZH group and 0. 06 g / kg dose of PZH group obviously decrease the tempreture（ P〈0. 05）,moreover the effect of PZH is in a dose-dependent manner. Meanwhile,Xiaocaihu granule group,0. 24 g /kg dose of PZH group,0. 12 g / kg dose of PZH group and 0. 06 g / kg dose of PZH group inhibited the generation of TNF-α,IL-1β,IL-8 and leukocyte,and they were significant comparing with model group（ P〈0. 05）. The effect of PZH is also in a dose-dependent manner. Conclusion： PZH has antipyretic and anti-inflammatory effects,it is similar to aspirin and better than Xiaocaihu granule.

关 键 词：片仔癀 大肠杆菌内毒素 解热抗炎 

分 类 号：R285.5[医药卫生—中药学]