星点设计-效应面法优化亚麻木酚素缓释片处方  

Optimization of Prescription of Flaxseed Lignans Sustained-release Tablets by Central Composite Design-response Surface Methodology

作　　者：刘效栓[1] 李季文[1] 吴晓琴[1] 舒劲[1] 焦正花[1] 钱梦茹[1] 毕映燕[1] 

机构地区：[1]甘肃省中医院,甘肃兰州730050

出　　处：《中国中医药信息杂志》2016年第4期87-90,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：甘肃省科技支撑计划(1104FKCA121)

摘　　要：目的采用星点设计-效应面法优化亚麻木酚素缓释片处方。方法以羟丙基甲基纤维素(HPMC)、乙基纤维素(EC)和淀粉的用量为考察因素,分别以亚麻木酚素在2、6、12 h的累积释放度为评价指标,采用星点设计-效应面优化法进行处方优选试验,并进行优化处方的验证分析。结果最终确定缓释片的最佳处方为HPMC用量为43%,EC用量为26%,淀粉用量为17%,优化处方的考察指标预测值与观察值非常接近。结论通过星点设计-效应面优化法建立的模型预测性良好,可用于亚麻木酚素缓释片处方的优化。Objective To optimize the prescription of flaxseed lignans sustained release tables by central composite design-response surface methodology.MethodsWith HPMC, EC and starch dosage as factors, and flaxseed lignans in 2, 6 and 12 h of cumulative release as evaluation indexes, central composite design-response surface optimization method was used to conduct prescription optimization experiments, and optimized prescription analysis was carried out.Results The optimal prescription of flaxseed lignans sustained release tables was as following: HPMC dosage was 43%; EC was 26%; starch content was 17%. Optimized index forecast values were very close to the observed values. In vitro release test of three selected optimal formulations indicated that there existed high approximation between the observed and estimated values.Conclusion It shows that the established model is suitable for flaxseed lignans sustained release tables, which can be used in the optimization of the prescription of flaxseed lignans sustained release tables.

关 键 词：亚麻木酚素 缓释片 星点设计-效应面法 

分 类 号：R283.5[医药卫生—中药学]