自噬与糖尿病肾病的研究进展  

Research progress between autophagy and diabetic nephropathy

作　　者：沈雪[1] 徐庆磊[1] 杨天舒[1] 吴晓昀[2] 蔡田[1] 董建军[3] 廖琳[4] 

机构地区：[1]山东中医药大学,济南250355 [2]山东大学,济南250014 [3]山东大学齐鲁医院内分泌科,济南250012 [4]山东省千佛山医院内分泌科,济南250014

出　　处：《中华临床医师杂志（电子版）》2016年第3期410-413,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(81570742;81070637);山东省科技发展计划(2010GSF10228;2012GGH11862;2014GSF118118);山东省自然基金(Y2006C76;Y2008C73;ZR2010HM044)

摘　　要：糖尿病已成为一种流行病,其慢性并发症糖尿病肾病的患病率随之增加,并缺乏有效的治疗方法,迫切需要寻找新的预防和治疗的药物或靶点。自噬作为机体主要防御机制之一,在器官和疾病代谢中发挥重要的作用,在糖尿病肾病中同样扮演着重要角色。研究表明,哺乳动物西罗莫司靶蛋白(m TOR)、AMP活化蛋白激酶(AMPK)和沉默信息调节因子1(Sir1)等营养信号通路对自噬有重要的调控作用,可能参与糖尿病肾病的发生发展,有望成为糖尿病肾病防治新的靶点。Diabetes has become an epidemic in the world. Its main chronic complication, diabetic nephropathy, increases gradually. However, there are lack of effective agents in its treatment. Autophagy, as one of main body defense mechanisms, plays an important role in maintaining the homeostasis of organs, and also in the development of diabetic nephropathy. Recent researches indicate that the nutrient-sensing signal pathways such as mammalian target of rapamycin（m TOR）, AMP-activated protein kinase（AMPK） and Sirt1, play a significant role in regulating autophagy and may contribute to the pathogenesis of diabetic nephropathy. That may be helpful in investigating a new target of diabetic nephropathy therapy.

关 键 词：糖尿病肾病 自噬 营养信号通路 

分 类 号：R587.2[医药卫生—内分泌]