辽东丁香枝化学成分的研究  

Chemical composition of Syringa wolfii C. K. Schneid's branches

作　　者：蔡恩博[1] 韩佳宏[2] 赵岩[1] 郑曼玲[1] 屠书梅 王大龙[1] 贾彩霞[1] 张晶[1] 

机构地区：[1]吉林农业大学中药材学院,吉林长春130118 [2]吉林省中医药科学院第一临床医院药剂科,吉林长春130021

出　　处：《上海中医药杂志》2016年第3期87-93,共7页Shanghai Journal of Traditional Chinese Medicine

基　　金：国家级大学生创新创业训练计划资助项目(2012022);吉林农业大学2012年本科生科技创新基金项目

摘　　要：目的研究辽东丁香树枝的化学成分。方法系统溶剂法对辽东丁香枝进行提取,并采用柱色谱、薄层色谱等分离手段对其进行分离纯化。水蒸气蒸馏法提取挥发油化学成分,利用GC-MS分析。结果鉴定出6种化合物,分别是:对苯二甲酸二甲酯(化合物1)、3-羟基-乌苏烷-12-烯(化合物2)、熊果酸(化合物3)、4-(2-羟乙基)-苯酚(化合物4)、D-甘露醇(化合物5)、丁香苷(化合物6);挥发油化学成分69种,占挥发油总量的99.86%,含量大的成分为2-甲基-5-(1-甲基乙基)-1-环戊烯醇(14.16%)。结论化合物3、5、6为首次从辽东丁香中分离得到,化合物1、2、4为首次从丁香属植物中分离得到。化合物2和6含量较大,为将来富集这两个化合物提供依据。挥发油中除了烷烃类外,其他类化合物部分成分含有萜类特征,其中烯烃类和氧化物类化合物中倍半萜成分所占比例最大。Objective To investigate the chemical compounds from the branch of Syringa wolfii C. K. Schneid. Methods The branch was subjected to the system solvent,and the obtained extracts were separated by column chromatography and thin layer chromatography. The volatile oil was extracted by water-steam distillation and analyzed by GC-MS. Results Six chemical compounds were identified,which included dimethyl terephthalate（ 1）,3-hydroxy-Ursane- 12-ene（ 2）,ursolicacid（ 3）,4-（ 2-hydroxyethyl）-phe-nol（ 4）,D-mannitol（ 5） and syringin（ 6）. 69 compounds were identified in essential oils,accounting for 99.86% of the total essential oil and 2-methyl-5-（ 1-methyl ethyl）-1-cyclopentene alcohol（ 14. 16%） was with the high content among them. Conclusion Compound 3,5 and 6 were obtained for the first time from the plant. Compound 1,2 and 4 were obtained in Syringa for the first time. Because the contents of 2and 4 were fairly high,which will provide protophase theoretical reference for the gathering of the two compounds from Syringa wolfii C. K. Schneid. Except for the alkanes,the most compounds were terpene. The analysis of the results show that sesquiterpenes was accounted for the largest portion in the alkene and the oxide compounds.

关 键 词：辽东丁香 化学成分 GC-MS 挥发油 

分 类 号：R284.1[医药卫生—中药学]