粟米草提取物抗大鼠缺血再灌注致心律失常的作用  

The effect of Mollugo pentaphylla extract on arrhythmia model rats induced by ischemia-reperfusion

作　　者：李兴暖[1] 龚帧[1] 刘莉萍[1] 钱隽[1] 

机构地区：[1]九江学院,江西九江332000

出　　处：《时珍国医国药》2016年第2期F0003-F0003,F0004,共2页Lishizhen Medicine and Materia Medica Research

基　　金：国家自然科学基金(No.81260606);江西省科技计划项目(No.2014BBG70084);江西省教育厅青年科学基金(No.GJJ11242);江西省卫生厅科技项目(No.20113138);九江学院校级重点科研项目(No.2014KJZD007)

摘　　要：目的研究粟米草提取物对心肌缺血再灌大鼠心律失常的影响。方法将SD大鼠随机分为假手术组、模型组、粟米草高、低剂量组和阳性药物组,给药3h后,制作心肌缺血再灌注模型,用BL-420F生物机能实验系统记录心电图,并对心电图进行分析。测定血清中CK和LDH活性,心肌组织Ca2+-ATPase活性。结果与模型对照组比较,粟米草提取物可降低大鼠心律失常发生率,显著降低缺血再灌注大鼠血清中CK和LDH水平和提高心肌组织中Ca2+-ATPase活性。结论粟米草提取物具有抗大鼠心肌缺血再灌注心律失常的作用。Objective To study the effect of Mollugo pentaphylla extract on myocardial ischemia reperfusion arrhythmia in rats. Methods SD rats were randomly divided into sham operation group, model group, Mollugo pentaphylla L. extract high, low dose group and positive drug group, After giving drug 3h, myocardial ischemia reperfusion model was made. The ECG were recorded and were analyzed. The activity of CK and LDH in serum, Ca2＋ - ATPase activity in myocardium was determined. Results Com- pare with the model control group Mollugo pentaphyUa extract can reduce the incidence of arrhythmias in rats, the serum CK and LDH levels and increase the activity of Ca2＋ - ATPase in myocardial tissue. Conclusion Mollugo pentaphyUa extract has the effect of anti rat myocardial ischemia - reperfusion arrhythmia.

关 键 词：粟米草 心肌缺血再灌注 心律失常 

分 类 号：R285.5[医药卫生—中药学]