成年代谢病的先天因素  

Maternal Factors of Adult Metabolic Diseases

作　　者：吕佳琪[1] 华雯妤 王恬[1] 

机构地区：[1]南京农业大学动物科技学院,江苏南京210095 [2]济南磐升生物技术有限公司,山东济南250101

出　　处：《动物医学进展》2016年第3期113-119,共7页Progress In Veterinary Medicine

基　　金：国家重点基础研究发展计划(973)(2012CB124703)

摘　　要：动物胚胎营养环境受母体营养供应与胎盘营养转运两方面影响。充足、合理的母体营养供应是胚胎健康发育的保障。不利的胚胎环境可以程序化胚胎发育,并持续影响代谢,导致成年后发生慢性疾病。论文探讨了胚胎期能量、蛋白质、微量元素、维生素和常量元素营养异常对胚胎发育和出生后代谢的影响;结合胎盘的结构,介绍了转运蛋白表达对胚胎葡萄糖、脂肪酸、氨基酸、胆固醇供应的影响;总结了胚胎发育程序化的形成机制。深入研究母体营养对后代代谢的长期影响,可以有效降低动物出生后代谢疾病的发生几率,有助于后代的健康生长,也为人类医学研究提供宝贵的借鉴和启发。Fetal nutrition is under the influence of both the maternal nutrition and placental nutrient transport.Adequate and appropriate supply of maternal nutrition is the guarantee of healthy fetal development.Adverse fetal environment can programme the embryonic development,cause lasting effects on the metabolism,leading to chronic diseases in adulthood.The article discussed the influence of abnormalities of energy,protein,major elements,vitimins and trace elements on the fetal development and metabolism after birth,introduced several transport proteins in the placenta that participate in the transporting of glucose,amino acid,fatty acids and cholesterol,and summarized the mechanism of developmental programming.The study of long-term effects of maternal nutrition will effectively reduce the incidence of adult metabolic diseases,contribute to the health of future generations,and provide reference and inspiration for the human medicine.

关 键 词：母体营养 胚胎发育 代谢程序化 慢性代谢病 

分 类 号：S852.33[农业科学—基础兽医学]