冠心病患者他汀类药物干预后LDL-C、TC变化与血小板CD62P表达的相关性研究  

A study on relationship of platelet CD62P expression,changes of LDL-C and TC after statin treatment in patients with coronary heart disease

作　　者：谭保平[1] 杨帆[1] 王红[1] 莫文宏[1] 

机构地区：[1]广西医科大学第四附属医院暨柳州市工人医院心内科,柳州545005

出　　处：《右江医学》2016年第1期10-13,共4页Chinese Youjiang Medical Journal

基　　金：广西壮族自治区科技厅资助项目(桂科攻10124001B-17);广西柳州市科技厅科研资助项目(2010030726)

摘　　要：目的研究冠心病患者采用他汀类药物干预后LDL-C、TC变化与血小板CD62P表达的相关性。方法将61例冠脉支架术后患者分为口服辛伐他汀组(20 mg/d)和瑞舒伐他汀组(10 mg/d),疗程均为1个月。治疗前后采用流式细胞术检测血小板CD62P表达的变化,同时检测血脂的变化,Person法分析治疗前后TC、LDL-C的变化与血小板CD62P表达变化的相关性。结果辛伐他汀组患者血小板CD62P表达率由治疗前的(19.37±14.78)%降至(4.91±5.48)%,TC和LDL-C水平由治疗前的(4.96±1.20)mmol/L和(3.58±1.81)mmol/L分别降至(4.18±0.49)mmol/L和(2.51±0.61)mmol/L,治疗前后比较差异有统计学意义(P<0.01)。瑞舒伐他汀组患者血小板CD62P表达率由治疗前的(13.79±11.28)%降至(3.72±4.56)%,TC和LDL-C水平由治疗前的(4.88±1.37)mmol/L和(3.30±1.06)mmol/L分别降至(3.81±1.00)mmol/L和(2.20±0.64)mmol/L,治疗前后比较差异有统计学意义(P<0.01)。但治疗前后两组间比较差异无统计学意义(P>0.05)。Person线性相关分析结果显示,两组患者治疗前后TC、LDL-C的降低值与血小板CD62P的降低值之间无相关性(P>0.05)。结论他汀类药物能改善冠脉支架术后患者血小板CD62P表达,可能是该药减少心血管事件发生的机制之一。Objective To study the relationship of platelet CD62 P expression and changes of LDL-C and TC after statin treatment in patients with coronary heart disease. Methods 61 patients with coronary stent implanted were divided into oral simvastatin group（ 20 mg / d） and rosuvastatin group（ 10 mg / d）,both groups were treated for 1 month. Changes of platelet CD62 P expression and levels of cholesterol before and after treatment were detected by flow cytometry. Meanwhile,Person liner regression analysis was used to analyze correlation of platelet CD62 P expression,changes of LDL-C and TC before and after treatment. Results After treatment,the expression rate of CD62 P in the simvastatin group decreased from（ 19. 37 ±14. 78） % to（ 4. 91 ± 5. 48） %,the levels of LDL-C and TC decreased from（ 4. 96 ± 1. 20） mmol / L and（ 3. 58 ± 1. 81）mmol / L to（ 4. 18 ± 0. 49） mmol / L and（ 2. 51 ± 0. 61） mmol / L,respectively. There were statistically significant differences when comparing to those before treatment（ P〈0. 01）. In addition,the expression rate of CD62 P in the rosuvastatin group decreased from（ 13. 79 ± 11. 28） % to（ 3. 72 ± 4. 56） %,the levels of LDL-C and TC decreased from（ 4. 88 ± 1. 37） mmol /L and（ 3. 30 ± 1. 06） mmol / L to（ 3. 81 ± 1. 00） mmol / L and（ 2. 20 ± 0. 64） mmol / L,respectively. There were statistically significant differences when comparing to those before treatment（ P〈0. 01）. However,no statistically significant differences were found when comparing those indexes between the two groups（ P〉0. 05）. Results of Person liner regression analysis showed that there were no correlation in reduced value between platelet CD62 P,LDL-C and TC before and after treatment（ P〉0. 05）. Conclusion Statins can improve platelet expression of CD62 P of the patients after intra coronary stenting,which may be one of the important mechanisms that statins reduce the incidence of cardiovascular events.

关 键 词：冠心病 他汀 血小板 CD62P 

分 类 号：R541.4[医药卫生—心血管疾病]