余甘子总黄酮提取物对H_1N_1流感病毒感染小鼠肺炎的影响  

The Influencw of Flavone Extract of Phyllanthus Emblica on Influenza H_1N_1 Virus Infected Pneumonia Mice

作　　者：孔秀娟[1] 于然[1] 刘建兴[1] 张莹[1] 胡秋萍[1] 劳梓钊 赖小平[1] 李耿[1] 

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《中医药导报》2016年第5期64-65,71,共3页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广东省自然科学基金团队项目(No.S201230006598)

摘　　要：目的:探讨余甘子黄酮提取物对感染H_1N_1流感病毒小鼠的保护作用及肺指数的影响。方法:以H_1N_1流感病毒感染小鼠建立模型,以利巴韦林为阳性药对照,不同浓度的余甘子黄酮提取物水溶液灌胃给药,统计各组小鼠平均存活时间及肺指数。结果:余甘子总黄酮高、中剂量组小鼠肺指数均低于模型组(P<0.01),余甘子总黄酮中剂量和高剂量可显著降低H_1N_1流感病毒小鼠肺指数;模型组小鼠存活时间明显低于正常组,差异有统计学意义(P<0.01)。余甘子总黄酮高、中剂量组小鼠存活时间高于模型组,差异有统计学意义(P<0.01),余甘子总黄酮高、中剂量可延长感染小鼠平均存活时间。结论:余甘子总黄酮提取物具有较好的抑制H_1N_1病毒感染小鼠肺部炎症的作用。Objective： To study the protection and the lung index inhibition of flavone extract from Phyllanthus emblica in H1N1 influenza virus infected mice. Methods： The mice were infected with influenza A （HjN3 virus. Different concentrate Phyllanthus emblica flavone extract were garage submission to influenza A （H1N1） virus infected mice, and ribavirin as positive contrast. Survival situation and the lung index of mice were observed after experiments. Results： High and middle concentration Phyllanthus emblica flavone groups showed lower lung index than the model group （P〈0.01）; High and middle concentration Phyllanthus emblica flavone can significantly inhibit the lung inflammation in H1N1 influenza virus infected mice. The Model group showed shorter survival time than the norma｜ group, with statistical difference （P〈0.01）; And the high and middle concentration Phyllanthus emblica flavone groups showed longer survival time than the modell group, with statistical difference （P〈0.01）. High and middle concentration Phyllanthus embfica flavone can prolong the survival time of mice. Conclusions： Phyllanthus emblica flavone could resistance pneumonia in H1N1 influenza virus infected mice.

关 键 词：余甘子总黄酮 H1N1流感病毒 利巴韦林 肺炎 小鼠 

分 类 号：R285.5[医药卫生—中药学]