ERAP1基因多态性和HLA-B27相互作用与强直性脊柱炎关联的研究进展  

Research Progress of Interaction Between ERAP1 Gene Polymorphism and HLA-B27 Associated with Ankylosing Spondylitis

作　　者：王玲[1] 奚永志[2] 孙玉英[2] 

机构地区：[1]安徽医科大学解放军307临床学院,北京100071 [2]安徽医科大学解放军307临床学院,军事医学科学院附属医院免疫学研究室暨国家生物医学分析中心免疫分析生物实验室,北京100071

出　　处：《生物技术通讯》2016年第1期124-127,共4页Letters in Biotechnology

摘　　要：HLA-B27阳性患者人群中,内质网氨基肽酶1(ERAP1)基因多态性与强直性脊柱炎(AS)密切相关。内质网中,ERAP1可有效剪切抗原肽,使其成为适合HLA-Ⅰ类分子提呈的寡肽。ERAP1基因多态性决定N端抗原肽修剪功能的正常与否以及HLA-B27分子的稳定表达。细胞水平的研究表明,不同ERAP1等位基因组合对于抗原肽底物的修剪能力决定了B27分子能否在细胞表面稳定表达。但是,功能型与功能异常型ERAP1如何影响HLA-B27抗原肽加工、B27稳定表达,以及如何影响AS疾病进程和免疫病理学改变等均未得到阐明。The endoplasmic reticulum aminopeptidase I（ERAP1） gene polymorphism is closely related to the au- kylosing Sspondilitis（AS） in HLA-B27 positive patients. In the endoplasmic reticulum, ERAP1 can effectively cut antigen peptide, making it suitable for HLA-I molecules. ERAP1 gene polymorphisms determine N terminal anti- gen peptide trim function is normal or not and stable expression of HLA-B27 molecules. The study of cellular lev- el found different ERAP1 gene combination for antigen peptide substrate clip ability determines the B27 molecules can be stable on the cell surface expression. Functional type and function abnormal ERAP1, however, is how to in- fluence the HLA-B27 antigen peptide processing, B27 stable expression and how to affect the AS disease process- es and immune pathology change, and so on has not been clarified.

关 键 词：强直性脊柱炎 内质网氨基肽酶1 HLA-B27 

分 类 号：R392.1[医药卫生—免疫学]