链脲佐菌素诱导糖尿病小鼠模型的心得体会  

Experience on the construction of diabetic mice model induced by streptozotocin

作　　者：郑国亚 齐佳[1] 刘顺梅[1] 连波[1] 陈丽梅[1] 尹金良[1] 

机构地区：[1]潍坊医学院生物科学与技术学院,山东潍坊261053

出　　处：《中国医药导报》2016年第6期182-185,共4页China Medical Herald

基　　金：山东省自然科学基金项目(ZR2010DM010);山东省高等学校科技计划项目(J10LC20);潍坊医学院科技创新基金(K1301009);潍坊医学院大学生创新基金(KX2015019)

摘　　要：链脲佐菌素是最常用的诱导动物发生糖尿病的药物。利用链脲佐菌素构建小鼠糖尿病模型的文献报道很多,但关于链脲佐菌素有效诱导小鼠糖尿病模型的关键因素及实验注意事项的报道却很少。本文总结了笔者在多次糖尿病小鼠建模实验中获得的一些经验与体会,以期为其他研究者开展糖尿病建模工作提供参考与指导作用。Streptozotocin （STZ） is the most widely used drug to produce animal model of diabetes mellitus. Many studies have been reported on the construction of STZ-induced diabetic mice model, but only scanty information is available on the detailed description of the key factors and details that should be pay attention to during establishment of the model. This paper summarizes the experiences of authors obtains from several times of producing diabetic mice model. The aim is to provide reference and instruction for other researchers.

关 键 词：链脲佐菌素 糖尿病 小鼠 模型 

分 类 号：R587.1[医药卫生—内分泌]