哺乳动物卵巢生殖干细胞的研究进展与争议  

Research progress and controversy of ovarian germ stem cells in mammals

作　　者：赵琰誉[1] 刘英[1] 

机构地区：[1]首都医科大学附属北京妇产医院生殖医学科,北京100026

出　　处：《生命科学》2016年第1期107-111,共5页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金项目(81471520);国家留学基金项目(2011911033);北京市自然科学基金项目(5122015);北京市卫生系统高层次卫生技术人才培养项目(2014-3-075)

摘　　要：关于雌性哺乳动物卵子再生的问题一直存有争议,1951年后人们普遍认为卵子数会随年龄增长而下降,不存在再生。近年来有学者对此提出质疑,他们在研究小鼠卵子凋亡时发现,卵巢内可能存在具有有丝分裂活性的生殖干细胞,随即引起了激烈讨论。虽然有一些实验结果对卵巢生殖干细胞的存在提出质疑,但是越来越多的研究提供了其存在的证据。卵巢生殖干细胞的研究一旦成熟,对基础及临床将具有深远影响。现对卵巢生殖干细胞的发现和研究现状及潜在应用展开综述。It is generally believed that postnatal female mammals had definite ovarian reserve and the follicles decreased with age. However in recent years, studies have shown that cells with mitotic activity may exist in mouse ovaries. Although the existence of ovarian germline stem cells is still unresolved at present, there is a growing number of studies revealing that female mammals may have a population of renewable cells in the ovaries. Once the research of ovarian germline stem cells has matured, it may have a profound impact on basic and clinical medicine. In this review, we mainly reviewed the history and current study development of ovarian germline stem cells in postnatal female mammals.

关 键 词：卵巢 生殖细胞 干细胞 卵子再生 

分 类 号：Q954.43[生物学—动物学]