我国西部汉族人IL-10基因多态性与肺结核易感性的相关性研究  

Association Analysis of IL-10 Gene Polymorphisms with Tuberculosis Susceptibility

作　　者：谭国超 徐春娟[1] 马纪龙[1] 边静[1] 温煜[1] 来力伟 张方琪[2] 成家军[2] 

机构地区：[1]解放军第三医院石坝河分院,宝鸡721006 [2]第四军医大学西京医院呼吸与危重症医学科,西安710032

出　　处：《中华肺部疾病杂志（电子版）》2016年第1期56-59,共4页Chinese Journal of Lung Diseases(Electronic Edition)

摘　　要：目的探讨白介素-10（IL-10）基因单核苷酸多态性与肺结核易感性的相关性,为肺结核的早期预警提供新的候选分子标志物。方法检测147例肺结核患者（病例组）及206例健康个体（对照组）中IL-10基因-819（C〉T）、-1 082（A〉G）多态位点基因型,进行关联分析。结果样本均衡性检验显示病例组与对照组个体之间在性别（P=0.575）、年龄（P=0.840）分布无统计学差异;基因分型检出率为99.7%;哈德温伯格平衡检测显示对照组个体符合遗传学规律（P值分别为0.137与0.311）;-819位点CC、CT、TT基因型分布在病例组与对照组间无统计学差异（P=0.901）;-1 082多态位点AA、AG、GG基因型在病例组中的分布频率分别为48.6%、43.2%和8.2%,而在对照组中分别为60.5%、36.1%和3.4%,二者之间存在统计学差异（P=0.032）,G为风险等位基因（OR=1.55,95%CI 1.10-2.19）。结论 IL-10基因-1 802（A〉G）位点单核苷酸多态性与我国西部汉族人群肺结核易感性显著相关,可作为该地区肺结核早期预警筛查的候选分子标志物。Objective To explore the association of tuberculosis susceptibility with IL-10 gene polymorphisms and to provide reference for early warning of tuberculosis. Methods 147 tuberculosis patients and 209 healthy individuals were enrolled. χ2test,T test and HWE test were conducted to examine the study populations,then the association between gene polymorphisms and tuberculosis susceptibility was analyzed.Results Sample balance test showed all of the cases in two groups were no statistical difference in sex（ P =0.575） and age（ P = 0. 840）. Genotyping detection rate was 99. 7%. Hardy Weinberg equilibrium detection showed the individual in control was conformed to the laws of genetics（ P = 0. 137,0. 311）. The genotype frequencies of IL-10_ 2 849 polymorphism between case and control were not statistically significant（ P =0.901）. While the difference of IL-10_ 1 082 polymorphism between case and control was identified（ P =0.032）. G is a risk alleles（ OR = 1.55,95%CI 1.10-2.19）. Conclusions-1 082 polymorphism of IL-10 gene is associated with tuberculosis susceptibility of northwest Han Chinese,which may be helpful for the early warning of tuberculosis.

关 键 词：肺结核 白介素-10 单核苷酸多态性 

分 类 号：R562[医药卫生—呼吸系统]