阿奇霉素联合利福霉素钠小剂量地塞米松对大叶肺炎患者血浆凝血酶调节蛋白和D-二聚体及降钙素原影响研究  

Effect of Azithromycin Combined with Rifamycin Sodium and Small doses of Dexamethasone on Thrombin Regulator Protein,D- two Protein and Calcitonin of Lobar Pneumonia Patients

作　　者：李倩 刘小媛 刘颖[2] 叶绿素 贺炜 

机构地区：[1]重庆市第六人民医院/重庆市职业病防治院,重庆400060 [2]第三军医大学西南医院内分泌科,重庆400037

出　　处：《河北医学》2016年第2期239-241,共3页Hebei Medicine

基　　金：重庆市卫生局医学科研面上项目;(编号:2013-2-430)

摘　　要：目的:探讨阿奇霉素联合利福霉素钠、小剂量地塞米松对大叶肺炎患者血浆凝血酶调节蛋白和D-二聚体及降钙素原的影响。方法:选取我院收治的大叶肺炎患者137例,根据治疗方法的不同,分为两组,实验组予阿奇霉素、利福霉素钠、小剂量地塞米松治疗。对照组予阿奇霉素治疗,7d为1个疗程,治疗1个疗程。治疗后,观察并比较两组患者的临床疗效,咳嗽、呼吸不畅、啰音等症状,以及血浆凝血酶调节蛋白、D-二聚体、降钙素原的变化。结果:与对照组相比较,实验组的临床疗效明显改善(P<0.05),临床症状缓解显著(P<0.05),血浆凝血酶调节蛋白、D-二聚体、降钙素原显著降低(P<0.05),差异均有统计学意义。结论:阿奇霉素联合利福霉素钠、小剂量地塞米松能够降低大叶肺炎患者血浆凝血酶调节蛋白、D-二聚体及降钙素原的水平,改善临床症状,疗效可靠,值得临床推广使用。Objective： To explore the effect of Azithromycin combined with rifamycin sodium and small doses of rexamethasone on thrombin regulator protein,D- two protein and calcitonin of lobar pnemonia patients. Method： 137 lobar pneumonia patients from our hospital were selected and divided into control group treated by azithromycin and experimental group treated by azithromycin,rifamycin sodium and small doses of dexamethasone. The clinical curative effect,cough,shortness of breath,rales,plasma thrombomodulin,two D- dimer and procalcitonin were compared between the two groups. Result： The clinical curative effect and clinical symptom relief were better in the experimental group than those in the control group,（ P〈0. 05）,the plasma thrombin regulatory protein,D- two and calcitonin in the experimental group were lower than those in the control group,（ P〈0. 05） there was statistical significance. Conclusion： Azithromycin combined with rifamyin sodium and small doses of dexamethasone can reduce the levels of thrombin regulator protein,D-two protein and calcitonin,improve the clinical symptoms,so the curative effect is reliable and worthy of clinical use.

关 键 词：阿奇霉素 利福霉素钠 小剂量地塞米松 大叶肺炎 

分 类 号：R563.1[医药卫生—呼吸系统]