氯米芬与他莫昔芬治疗多囊卵巢综合症不孕患者临床疗效对比观察  

Clinical Efficacy of Clomiphene and Tamoxifen on Infertility Patients with Polycystic Ovary Syndrome

作　　者：向大清 陈玲[2] 曾林[3] 

机构地区：[1]四川省交通厅公路局医院妇产科,四川郫县611731 [2]四川省都江堰市人民医院妇产科,四川都江堰611830 [3]四川大学华西医院,四川成都610041

出　　处：《河北医学》2016年第2期284-287,共4页Hebei Medicine

基　　金：四川省科技厅资助项目;(编号:2012SZ0258)

摘　　要：目的:对比分析氯米芬与他莫昔芬对多囊卵巢综合症不孕患者的临床疗效。方法:根据随机数字表法将本组纳入的98例患者随机分为A组(n=49)和B组(n=49)。A组给予他莫昔芬治疗,B组给予氯米芬治疗。两组均连续服用21d为1个疗程,连续服用3个疗程。对比分析两组治疗前后卵巢体积、卵泡数、LH、T、FSH及治疗后排卵率、妊娠率。结果:两组卵巢体积和卵泡数均显著低于治疗前,且具有统计学差异(P<0.05);A组卵巢体积和卵泡数治疗后显著低于B组,且具有统计学差异(P<0.05);两组LH、T治疗后较治疗前显著降低,而FSH治疗后较治疗前增加,且均具有统计学差异(P<0.05);A组LH、T治疗后显著低于B组,FSH治疗后显著高于B组,且均具有统计学差异(P<0.05);A组排卵率(85.71%)和妊娠率(38.78%)显著高于B组排卵率(67.35%)和妊娠率(18.37%),且具有统计学差异(P<0.05);治疗期间两组患者均未发生明显不良反应。结论:他莫昔芬治疗多囊卵巢综合症不孕患者临床疗效显著优于氯米芬。Objective： To compare the clinical efficacy of clomiphene and tamoxifen on infertile patients with polycystic ovary syndrome. Method： According to the random number table,98 patients were randomly divided into group A（ n = 49） and group B（ n = 49）. Group A were given tamoxifen therapy,group B received clomiphene treatment. After three courses of treatment（ with 21 days as a course of treatment）. Comparatively analysis was conducted on ovarian volume,number of follicles,LH,T,FSH before and after treatment as well as ovulation and pregnancy rate after treatment. Result： The ovarian volume and follicle number in the two groups were significantly lower than those before treatment,and had a statistically significant difference（ P〈0. 05）; the ovarian volume and follicle number in group A were significantly lower than those in group B,and had a statistically significant difference（ P〈0. 05）; compared with before treatment,LH and T after treatment significantly decreased,while FSH increased after treatment,and was statistically different（ P〈0. 05）; LH and T in group A after treatment was significantly lower than those in group B,FSH was significantly higher than that in group B,and both had significant differences（ P〈0. 05）; the ovulation rate（ 85. 71%） and pregnancy rate（ 38. 78%） of group A was significantly higher than those of group B,and had a statistically significant difference（ P〈0. 05）; There were no obvious adverse reactions during treatment in both groups of patients. Conclusion： Clinical efficacy of tamoxifen for infertility patients with polycystic ovary syndrome is significantly better than that of clomiphene.

关 键 词：氯米芬 他莫昔芬 多囊卵巢综合征 不孕 

分 类 号：R711.75[医药卫生—妇产科学]