急性呼吸窘迫综合征患者白介素6及白介素8水平变化研究  

Changes of the Levels of Interleukin 6 and Interleukin 8 in Patients With Acute Respiratory Distress Syndrome

作　　者：陈晖[1] 王丹[1] 李亚明[1] 张进召[1] 兀威[1] 

机构地区：[1]西安医学院第一附属医院呼吸与危重症医学科,陕西省西安市710077

出　　处：《中国全科医学》2016年第5期538-541,共4页Chinese General Practice

基　　金：西安医学院第一附属医院基金资助项目(XYFY10-12)

摘　　要：目的探讨白介素6(IL-6)及白介素8(IL-8)在急性呼吸窘迫综合征(ARDS)发病过程中的水平变化。方法纳入西安医学院第一附属医院呼吸与危重症医学科2010年12月—2013年2月收治的50例ARDS患者,按预后分为治愈组(30例)和死亡组(20例),检测患者入院第1天及治愈组出院前最后1次,死亡组死亡前最后1次血清IL-6及IL-8水平。选择同期50例健康体检者作为对照组,并检测对照组血清IL-6及IL-8水平。采用SPSS 19.0统计软件进行统计学处理。结果 ARDS组患者入院第1天血清IL-6及IL-8水平〔(2.1±1.8)、(639.6±98.3)ng/L〕明显高于对照组〔(1.1±0.2)、(415.9±56.8)ng/L〕,差异均有统计学意义(P<0.01)。死亡组IL-6及IL-8血清水平〔(3.8±0.2)、(687.8±70.2)ng/L〕高于治愈组〔(1.8±0.4)、(493.9±71.7)ng/L〕及对照组,差异均有统计学意义(P<0.01);治愈组血清IL-6及IL-8水平均高于对照组,差异均有统计学意义(P<0.01)。结论 ARDS死亡组患者血清IL-6和IL-8水平显著增高,推测IL-6和IL-8在ARDS的发病过程中发挥着重要作用。Objective To investigate the changes of the levels of interleukin 6（ IL-6） and interleukin 8（ IL-8） in the pathogenetic process of acute respiratory distress syndrome（ ARDS）. Methods We enrolled 50 ARDS patients who were admitted into the Department of Respiratory and Critical Care Medicine of the First Affiliated Hospital of Xi＇an Medical University from December 2010 to February 2013. The patients were divided into cure group（ 30 patients） and a non- survival group（ 20patients）. The levels of serum IL-6 and IL-8 were measured on day 1 after admission and right before discharge for cure group and were also measured right before death for non- survival group. We also enrolled 50 healthy subjects as control group,and the levels of serum IL-6 and IL-8 were detected. SPSS 19. 0 statistical software was employed to conduct statistical treatment. Results ARDS group was higher（ P 〈0. 01） than control group in the levels of serum IL-6 〔（ 2. 1 ± 1. 8） ng / L vs.（ 1. 1 ± 0. 2） ng /L〕and IL-8 〔（ 639. 6 ± 98. 3） ng / L vs.（ 415. 9 ± 56. 8） ng / L〕. Non- survival group was higher（ P 〈0. 01） than cure group in the levels of serum IL-6 〔（ 3. 8 ± 0. 2） ng / L vs.（ 1. 8 ± 0. 4） ng / L〕and IL-8 〔（ 687. 8 ± 70. 2） ng / L vs.（ 493. 9± 71. 7） ng / L〕,and cure group and non- survival group were all higher（ P 〈0. 01） than control group in the two levels.Conclusion The levels of serum IL-6 and IL-8 play an important role in the development of ARDS,and the non- survival group is significantly higher in the level of serum IL-6 and IL-8.

关 键 词：白细胞介素6 白细胞介素8 呼吸窘迫综合征 成人 

分 类 号：R563.8[医药卫生—呼吸系统]