泻黄散对小儿脾胃积热型过敏性紫癜Th1/Th2的影响  

Impact on Th1/Th2 of Using Xiehuang Powder in Children with Allergic Purpura Which was Spleen-stomach Heat Accumulation Type

作　　者：杜红霞[1] 杨昆[1] 王飞[1] 卢野[1] 李叶雨[1] 陈燕子[1] 

机构地区：[1]成都中医药大学临床医学院/附属医院儿科,四川成都610075

出　　处：《四川中医》2016年第2期92-95,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：四川省教育厅资助项目(编号:12ZA029)

摘　　要：目的:观察泻黄散早期干预治疗脾胃积热所致皮肤型HSP的临床疗效及免疫学变化,探讨临床疗效和免疫调节之间的关系,进一步阐明该方在脾胃积热所致皮肤型HSP应用中的作用机理。方法:收集脾胃积热所致皮肤型HSP患者60例,随机分成两组,西医治疗组和中西医结合治疗组,并建立正常儿童对照组20例,观察疗程2周,随访6个月。测定治疗前后外周血IL-12、IL-6水平。结果:急性期西医组、中西医结合组IL-6水平均显著高于正常对照组,IL-12水平均低于正常对照组,(P<0.05)有统计学意义。2周疗程后,中西医结合组IL-6、IL-12水平与正常对照组比较(P>0.05)无统计学意义。西医组IL-12水平与正常对照组比较(P>0.05)无统计学意义,但IL-6水平与正常对照组比较(P<0.05)有统计学差异。中西医结合组总有效率96.67%,西医组总有效率86.70%,两者比较(P<0.05)有统计学意义;且经过6个月的回访,中西医结合组复发率为3.45%,西医组复发率为15.38%,两者比较(P<0.05)有统计学意义。结论:泻黄散结合西药常规治疗脾胃积热所致皮肤型HSP可更有效逆转Th2亢进状态,使病情得到改善和防止进展,其疗效机制与免疫功能调控相关。Objective： To observe the clinical efficacy and immunological changes of using Xiehuang Powder to early intervene and treat skin type of HSP caused by spleen- stomach heat accumulation,exploring the relationship between clinical efficacy and immune regulation,to further clarify the party due to heat accumulation in the spleen and skin mechanism type HSP applications. Methods： 60 cases of spleen- stomach heat accumulation caused skin type HSP patients were randomly divided into two groups,western medicine treatment group and the combination therapy group,and the establishment of normal children in the controlled group with 20 cases,they were observed for 2weeks,followed up for 6months. Measured before and after treatment of peripheral blood IL- 12,IL- 6levels. Results： The acute phase,IL- 6levels of the western medicine treatment group and the integrative medicine group were significantly higher than the controlled group,IL- 12 levels were lower than the controlled group,（ P〈0. 05） were statistically significant. After two weeks of treatment,IL- 6,IL- 12 levels of the integrative medicine group and the normal control group（ P〈0. 05） was not statistically significant. IL- 12 level of western medicine treatment group and the normal controlled group（ P〈0. 05） was not statistically significant,but IL- 6level was significantly different（ P〈0. 05）compared with the normal controlled group. The total efficiency rate of integrative medicine treatment group was 96. 67%,the total efficiency rate of the western medicine treatment group was 86. 70%,it was statistically significant between the two groups（ P〈0. 05）; and after six months of observation,integrative medicine group recurrence rate was 3. 45%,the recurrence rate of the western group was 15. 38%,it was statistically significant（ P〈0. 05） between the two group. Conclusion： Using Xiehuang Powder combined with conventional western medicine in the treatment of skin type HSP caused by spleen- stomach heat accumulation can be more

关 键 词：过敏性紫癜 泻黄散 脾胃积热 T辅助细胞1/T辅助细胞2 

分 类 号：R554.6[医药卫生—血液循环系统疾病]