他汀联合治疗性生活方式改变对血脂异常患者的效果评价  

The effectiveness evaluation of statins and therapeutic lifestyle changes for the patients with dyslipidemia

作　　者：唐慧芸 姜盈缨 金丽茵 陈晔 潘桂俊 

机构地区：[1]上海市浦东新区金杨社区卫生服务中心全科,上海200136 [2]上海市浦东新区金杨社区卫生服务中心检验科

出　　处：《中华全科医学》2016年第3期431-434,共4页Chinese Journal of General Practice

基　　金：上海市浦东新区科技发展基金创新资金(PKWY2012-Y41);上海市浦东新区系统优秀社区适宜人才培养项目(PWRs2014-02)

摘　　要：目的探讨他汀类药物联合治疗性生活方式改变(TLC)对社区血脂异常患者的效果评价。方法选择社区内符合他汀类药物治疗的血脂异常患者231例,计算机随机分成2组:干预组112例,给予他汀联合TLC的综合干预;对照组119例,给予他汀治疗及门诊常规的血脂异常知识教育。分别测得2组治疗前、治疗3个月后的总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、空腹血糖(Glu)水平,统计干预组干预前、后的健康知识问卷成绩。结果干预3个月后,干预组TC、TG、LDL-C、Glu水平均较治疗前降低,差异有统计学意义(P<0.05),对照组患者只有TC、LDL-C水平较治疗前降低,差异有统计学意义(P<0.05),TG、Glu水平较治疗前无明显变化,差异无统计学意义(P>0.05),2组的HDL-C较治疗前均无明显变化,差异无统计学意义(P>0.05);组间比较,治疗3个月后干预组的患者TC、TG、LDL-C和Glu水平低于对照组,差异有统计学意义(P<0.05);干预组的健康知识问卷成绩,干预前后比较,差异有统计学意义(P<0.001)。结论社区综合防治干预对血脂异常患者的效果更好,TLC是血脂异常患者治疗的基础措施。Objective To study the effectiveness evaluation of statins treatment and therapeutic lifestyle changes for the patients with dyslipidemia. Methods Two hundred and thirty-one patients with dyslipidemia in the community conform to statin therapy,were randomly divided into two groups,112 cases in the intervention group,give TLC combined with statin treatment,119 cases in the control group,only to give the knowledge related to statin therapy and general dyslipidemia education. Before and after the treatment,the TC,TG,LDL-C,HDL-C,G level of the two groups were test and health knowledge questionnaire scores in the intervention group. Results After 3 months of intervention,the TC,TG,LDL-C,G levels of intervention group were lower than before（ P〈0. 05）,but the patients in the control group only TC,LDL-C levels lower than before（ P〈0. 05）,TG,G had no obvious change（ P〉0. 05）,HDL-C of the two groups had no obvious change（ P〈0. 05）; comparison with TC,TG,LDL-C and G between two groups,the treatment group were lower than the control group（ P〈0. 05）; health knowledge questionnaire scores were higher than before after intervention（ P〈0. 001）. Conclusion The effect of community comprehensive prevention and treatment on patients with dyslipidemia is more effective,the TLC is the basic measures of treatment of patients with dyslipidemia.

关 键 词：血脂异常 他汀类药物 治疗性生活方式改变 

分 类 号：R589.2[医药卫生—内分泌] R972.6[医药卫生—内科学]