米非司酮配合舌下含服低剂量米索前列醇的催经止孕的效果观察  

Observation of the Effect on Mifepristone Combined With Low Dose Misoprostol Under the Tongue in Menstruation and Terminating Pregnan

作　　者：薛海峰 

机构地区：[1]河南省偃师市人民医院妇产科,471900

出　　处：《中国继续医学教育》2016年第5期167-168,共2页China Continuing Medical Education

摘　　要：目的探讨米非司酮配合舌下含服低剂量米索前列醇的催经止孕效果及安全性。方法收集2012年5月-2014年8月在我院门诊就诊的月经延迟妇女120例。采用随机数字表法将患者分为试验组和对照组,每组60例。对照组按常规口服米非司酮和米索前列醇催经止孕。试验组采用米非司酮联合低剂量米索前列醇舌下含服催经止孕。比较两组的治疗结局：完全流产、不全流产、异位妊娠、月经来潮、失败情况。同时观察两组服药期间不良反应及阴道流血情况。结果试验组和对照组的完全流产率、不完全流产率、异位妊娠率、月经来潮率、失败率比较差异无统计学意义（P〉0.05）。治疗期间,试验组患者恶心、呕吐及腹泻发生率低于对照组,差异有统计学意义（P〈0.05）。试验组、对照组的阴道流血时间比较差异无统计学意义（P〉0.05）。结论米非司酮联合舌下含服小剂量米索前列醇对经期延迟不足1周的女性,能起到较佳的催经止孕的效果,其能减少消化道症状的发生。Objective To investigate the effect and safety of mifepristone combined with low dose misoprostol under the tongue in menstruation and terminating pregnan. Methods 120 delayed menstruation women who doctored in our hospital from May 2012 to August 2014 were collected. They were randomly divided into experimental group and control group, there were 60 patientes in each group. The control group were received routine oral mifepristone and misoprostol for menstruation and terminating pregnan. The experimental group was treated with mifepristone combined with low dose of misoprostol under the tongue, the treatment outcome： complete abortion, incomplete abortion, ectopic pregnancy, menstruation, failure were compared between the two groups. And the adverse reactions and vaginal bleeding were observered between the two groups. Results The complete abortion rate, incomplete abortion rate, ectopic pregnancy rate, menstrual cramps rate, failure rate between experimental group and control group had no significant difference（P〈0.05）. The incidence of nausea, vomiting and diarrhea in the experimental group was significantly lower than that in the control group（P〈0.05）. The vaginal bleeding time had no significant difference between the experimental group and the control group（P〈0.05）. Conclusion To women with menstruation delay, mifepristone combined with misoprostol low dose of misoprostol under the tongue in treatment can play a better effect, which can reduce the occurrence of gastrointestinal symptoms.

关 键 词：米非司酮 舌下含服 米索前列醇 催经止孕 

分 类 号：R169.4[医药卫生—公共卫生与预防医学]