吲达帕胺联合卡维地洛治疗顽固性高血压的疗效及其对糖脂代谢的影响  

The Efficacy of Indapamide Combined With Carvedilol in Treatment of Resistant Hypertension and Glucose and Lipid Metabolism

作　　者：李雪[1] 

机构地区：[1]新乡医学院第五附属医院干部病房,453000

出　　处：《中国卫生标准管理》2016年第2期110-112,共3页China Health Standard Management

摘　　要：目的探讨吲达帕胺联合卡维地洛治疗顽固性高血压的疗效及其对糖脂代谢影响。方法 2014年6月-2015年6月,我院收治顽固性高血压患者90例,随机分为观察组和对照组各45例。观察组采用吲达帕胺联合卡维地洛治疗,对照组采用吲达帕胺治疗。对两组患者治疗6个月后的尿微量蛋白、尿肌酐、24 h动态血压、血清尿酸以及糖脂代谢指标等进行检测,对比治疗疗效。结果两组尿微量蛋白、尿肌酐、24 h动态血压、血清尿酸等相关指标变化,比较差异均有统计学意义（P〈0.05）。两组FBG比较差异无统计学意义（P〉0.05）。两组TC、TG、HLD和LDL比较,差异均有统计学意义（P〈0.05）。结论吲达帕胺联合卡维地洛治疗顽固性高血压的疗效好,并且对脂类的代谢有着很好的调节作用,有利于血压的降低和控制。Objective To investigate the efficacy of indapamide combined with carvedilol in treatment of resistant hypertension and glucose and lipid metabolism. Methods From June 2014 to June 2015,there were 90 cases of patients with resistant hypertension were randomly divided into two groups,45 cases in each group. Observation group used indapanmide carvedilol therapy,the control group with indapamide therapy. Two groups of patients after six months,microalbuminuria,urine creatinine,24-hour ambulatory blood pressure,serum uric acid and lipid metabolism indicators were detected. Results Two groups of patients＇ microalbuminuria,urine creatinine,24-hour ambulatory blood pressure,serum uric acid and other related indicators,the difference was statistically significant（P〈0.05）. FBG difference between the two groups was not statistically significant（P〈0.05）. Groups＇ TC,TG,HLD and LDL,the difference was statistically significant（P〈0.05）. Conclusion Combined indapanmide with carvedilol in the treatment of resistant hypertension have better efficacy and lipid metabolism has a good regulation,and in favor of lower and control blood pressure.

关 键 词：吲达帕胺 卡维地洛 顽固性高血压 糖脂代谢 

分 类 号：R544.1[医药卫生—心血管疾病]