白细胞介素-1基因多态性与冠心病关系研究  

Study on the Relationship Between Interleukin-1 Gene Polymorphism and Coronary Heart Disease

作　　者：梁皓[1] 

机构地区：[1]河南省濮阳市人民医院,457000

出　　处：《中国卫生标准管理》2016年第2期182-183,共2页China Health Standard Management

摘　　要：目的分析、研讨白细胞介素-1(Interleukin-1)基因多态性与冠心病关系。方法研究白细胞介素-1B基因(Interleukin-1B,IL-1B)启动子区域-31位点和-511位点和白细胞介素-1受体拮抗剂基因(Interleukin-1 receptor antagonist,IL-1RN)基因多态性,对其在河南省汉族人群中的分布进行描述。通过相关的方法对于相应的基因实施实际的分析以及检测,并找出基因的多态性情况,对结果进行探讨。结果 IL-1B-31、IL-1B-511基因多态性及IL-1RN VNTR多态性的基因型及等位基因频率均符合Hardy-Weinberg遗传平衡,具有群体代表性;基因频率分布存在着人群和地区差异。结论 IL-1B-511T/T基因型是患心脏疾病的最为主要的因素。但在冠心病患者实际的发病过程中,IL-1B-31、IL-1RN基因不会出现任何的影响,因此对冠心病不起作用。Objective To analyze and study the relationship of interleukin-1 gene polymorphism and coronary heart disease. Methods Research on Interleukin-1B start sub region-31 site and site 511 and interleukin-1 receptor antagonist gene polymorphism,on its distribution in Han of Henan Province population described. Through the relevant methods for the actual implementation of the corresponding gene analysis and detection to identify polymorphisms of genes,andto discuss the results. Results IL-1B-31 and IL-1B-511 gene polymorphism and IL-1RN VNTR polymorphism genotype and allele frequency were in accordance with Hardy Weinberg equilibrium,had the characteristic of group representation. Gene frequency distribution had differences in population and area. Conclusion IL-1B-511T/T genotype is the main factor for heart disease. But in the actual process of morbidity in patients with coronary heart disease, IL-1B-31 gene,IL-1RN will have not any effect,it has no effect on coronary heart disease.

关 键 词：冠心病 基因多态性 白细胞介素-1 

分 类 号：R541.4[医药卫生—心血管疾病]