大光斑、低能量激光辅以还原性谷胱苷肽和积雪甙治疗黄褐斑临床疗效分析  

Clinical experience of broad beam and low-energy Q switched ND:YAG laser and reduced glutathione with centella asiatica treating chloasma

作　　者：吴晓勇[1] 陈一松[1] 孙碧梅 

机构地区：[1]东南大学附属江阴医院医疗美容科,江苏江阴214400

出　　处：《中国美容医学》2016年第2期50-52,共3页Chinese Journal of Aesthetic Medicine

摘　　要：目的:探讨大光斑、低能量激光辅以还原性谷胱苷肽和积雪甙治疗黄褐斑的临床疗效。方法:40例黄褐斑患者,随机分为两组,对照组:20例,使用波长1 064nm、频率10Hz、光斑直径8mm以及能量密度2.0~3.3J/cm^2的大光斑低能量调Q开关激光治疗,每周1次,4次为1个疗程,治疗2个疗程;治疗组:20例,在对照组治疗的基础上辅以电子注射器面部注射还原性谷胱苷肽,外用积雪甙霜。还原性谷胱苷肽0.3g加入生理盐水溶解为3.5ml,根据面部黄褐斑具体部位调整注射深度0.8~1.2mm,根据黄褐斑范围调整每次注入量,设定返回比例为30%。积雪甙霜外用每日3次,维持全部疗程。结果:治疗1个疗程后,对照组总有效率为45.0%,治疗组总有效率为55.0%。治疗2个疗程后,对照组总有效率为85.0%.治疗组总有效率为95.0%。两组治疗1个疗程后,总有效率比较P^1>0.05,但治疗组有效率高于对照组,总显效率比较P^2<0.05;两组治疗2个疗程后,总有效率比较P^3>0.05,但治疗组有效率高于对照组,总显效率P^4<0.05。结论:大光斑、低能量激光辅以还原性谷胱苷肽和积雪甙霜治疗黄褐斑是一种有效的方法。Objective To explore the clinical effect of broad beam and low-energy Q switched ND：YAG laser and reduced glutathione with centella asiatica treating chloasma. Methods All patients（40cases） were divided into two groups,control group and treatment group, control group was treated with broad beam and low-energy Q switched ND：YAG laser（wave le ngth：1064nm,frequency：10Hz,beam diameter： 8mm,energy density： 2.0-3.3 J/cm^2） lasting once a week,and 4 times for a course,2 courses together. Treatment group was treated with reduced glutathione and centella asiatica besides the methods of control group. Reduced glutathione was dissolved into normal saline up 3.5ml,we needed to change the injection depth from 0.8mmto 1.2mm according to the area of chloasma. And according to the dimension of chloasma,the volume of injecton was changed.30% return rate was designed.Centella asiatica was used 3 times a day during the treatment. Results After one course, the total effect was 45.0% in control group. In treatment group, the total effect was 55.0%. After two courses, the total effect rate was 85.0% in control group while in treatment group, it was 95.0%. After a course, the proportion of total effect between control group and treatment group was P^1〉0.05,but the treatment was higher than the control group P^2〈0.05. After two courses, total effect rate between control group and treatment group was P^3〉0.05,but the treatment group was still higher than the control group P^4〈0.05. Conclusion It is a valuable method for chloasma to use large-sport and low-energy Q switched ND：YAG laser and reduced glutathione with centella asiatica.

关 键 词：大光斑低能量 激光 还原性谷胱苷肽 积雪甙 黄褐斑 电子注射 

分 类 号：R758.42[医药卫生—皮肤病学与性病学]