秀丽隐杆线虫在抗衰老领域应用的研究进展  

Advances in researches on the anti-aging of Caenorhabditis elegans

作　　者：游牧[1] 胡云虎[2] 

机构地区：[1]淮南联合大学医学系,安徽淮南232038 [2]淮南师范学院化学与材料工程学院,安徽淮南232038

出　　处：《中国美容医学》2016年第2期104-107,共4页Chinese Journal of Aesthetic Medicine

基　　金：安徽省高校自然科学重点研究项目(KJ2015A349);安徽省高校质量工程项目(2014jyxm472)

摘　　要：秀丽隐杆线虫(Caenorhabditis elegans)是抗衰老研究中重要的模式生物之一,被广泛应用于抗衰老物质的筛选和抗衰老分子机制的研究中。本文回顾了近年来秀丽隐杆线虫在抗衰老领域应用的研究进展,介绍了抗衰老物质的筛选情况,系统综述了作为抗衰老物质筛选评价的生理指标和反映抗衰老机制的生化指标包括寿命、生存率、生存时间、ROS含量、脂褐质积累以及daf-16,sod-3,gst-4,hsps基因调控情况等,指出了研究中存在的问题,展望了秀丽隐杆线虫在抗衰老研究中的应用前景。Caenorhabditis elegans is one of the most important model organisms,and is widely used in evaluation of anti-aging substance and mechanism study.This article reviewed the application of Caenorhabditis elegans research progress in the field of anti-aging in recent years,introduced the screening of anti-aging substance,summarized some indexes such as lifespan, survival rates,survival time, ROS,lipofuscin,daf-16,sod-3,gst-4 and hsps.The unresolved problems were pointed out and the possible ways to solve these problems were expounded.Finally a prospect of the application in anti-aging research was analyzed.This paper can provide useful information for researchers in related fields.

关 键 词：抗衰老 秀丽隐杆线虫 生理指标 生化指标 

分 类 号：R339.38[医药卫生—人体生理学]