维生素D对2型糖尿病合并呼吸道感染患者的临床研究  

Study on the vitamin D in the treatment of type 2 diabetic patients with respiratory tract infections

作　　者：张永敬[1] 么焕新 柴颖[1] 王淑珍[1] 

机构地区：[1]唐山市协和医院老年病科,河北唐山063000

出　　处：《中国临床药理学杂志》2016年第5期390-392,共3页The Chinese Journal of Clinical Pharmacology

基　　金：唐山市科技局计划基金资助项目(121302126a)

摘　　要：目的观察维生素D对2型糖尿病患者合并呼吸道感染患者的临床疗效。方法 60例2型糖尿病合并呼吸道感染患者随机分为对照组30例和试验组30例。2组均常规抗感染及胰岛素强化治疗,对照组口服自制安慰剂胶丸1丸,每日1次;试验组口服骨化三醇胶丸1丸,每日1次,均连续服用24周。比较2组患者治疗前和治疗后4,24周血清葡萄糖、血清钙、25羟维生素D3[25(OH)D_3]及免疫因子分化簇3(CD_3)、分化簇4(CD_4)、补体C3、免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)水平。结果治疗后,2组患者血糖水平显著低于治疗前(P<0.05),试验组25(OH)D3水平升高,且高于对照组(P<0.05);治疗后,2组患者CD4水平升高(P<0.05),且试验组高于对照组(P<0.05);治疗后,2组患者免疫球蛋白A水平下降,免疫球蛋白G、C3水平上升(P<0.05),且试验组免疫球蛋白A水平较低,免疫球蛋白G、C3水平较高(P<0.05)。结论口服维生素D对于2型糖尿病合并呼吸道感染患者能够显著提高补体水平。Objective To evaluate the effect of the vitamin D in patients with type 2 diabetic combine with respiratory tract infections. Methods A total of 60 patients with type 2 diabetic combine with respiratory tract infections were selected and randomly divided into the control group and the treatment group,30 cases in each group. Two groups were both treated by routine antiinfection and insulin intensive therapy. The control group were added homemade placebo capsule 1 pills,1 times a day and the trial group added calcitriol soft capsules 1 pills,1 times a day,two groups were taken for24 weeks. The serum glucose,serum Ca,25（ OH） D3 and CD_3,CD_4,C3,immunoglobulin A（ Ig A） and Ig G were tested and compared before and after treatment. Results Compared with before treatment,the blood glucose level were lower（ P〈0. 05）,the levels of 25（ OH） D3 in the treatment group were higher than in the control group（ P〈0. 05）. Compared with before treatment,the CD_4 level were higher（ P〈0. 05）,the treatment group were more obviously（ P〈0. 05）. Compared with before treatment,the Ig A level were lower（ P〈0. 05）,the Ig G,C3 level were higher（ P〈0. 05）,and the treatment group were more obviously（ P〈0. 05）. Conclusion Oral vitamin D can significantly improve the level of complement in patients with type 2diabetes mellitus combined with respiratory tract infection.

关 键 词：维生素D 2型糖尿病 呼吸道感染 免疫因子 

分 类 号：R977.24[医药卫生—药品] R587.1[医药卫生—药学]