GATA-4翻译后修饰在心脏发育与功能发挥中的作用  

Post-translational modification of GATA- 4 in heart development and its function exertion

作　　者：刘扬[1] 薛丽香[1] 

机构地区：[1]北京大学第三医院中心实验室,肿瘤放疗科,北京100191

出　　处：《生命的化学》2016年第1期97-104,共8页Chemistry of Life

基　　金：北京大学创新人才培养计划

摘　　要：GATA-4是转录因子GATA家族的成员之一,在心脏发育中发挥着不可缺少的作用,它可以应答心肌细胞的肥大刺激,激活抗凋亡蛋白的表达并促进细胞存活等。GATA-4在心脏发育中的调节机制一直是科学家们研究的热点。本文对GATA-4在心脏发育中的作用及机制进行了总结,并重点对GATA-4的磷酸化、乙酰化、甲基化以及苏素化等翻译后修饰及其表观遗传学机制等进行了综述。GATA-4 is a member of the GATA family and plays the essential roles in heart development. GATA-4 is involved in cardiomyocyte hypertrophy, the activation of antiapoptotic proteins＇ expression, and in promoting cardiomyocyte survival, and so on. Mechanism of GATA-4 regulation in heart development has been the focus in the field. In this paper, we have summarized the role and mechanism of GATA-4 in heart development and expounded the post-translational modifications such as phosphorylation, acetylation, methylation and sumoylation post-translational modification and epigenetic regulation of GATA-4 particularly.

关 键 词：GATA-4 心脏发育 翻译后修饰 表观遗传机制 

分 类 号：Q344[生物学—遗传学] R346[医药卫生—基础医学]