丹参中酚酸类成分在不同工艺条件下转化关系  

Transformation Relationship of Salvianolic Acids in Salviae Miltiorrhizae Radix et Rhizoma Under Heating,pH Conditions

作　　者：彭九嫚 柴尧 潘旻[1] 陈丽叶[1] 郑云枫[1] 程建明[1] 

机构地区：[1]南京中医药大学药学院,南京210046

出　　处：《中国实验方剂学杂志》2016年第5期67-70,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：江苏省高校自然科学基金项目(13KJD360004)

摘　　要：目的:研究提取时间、碱处理、转化时间等因素对丹参中酚酸类成分水解转化规律影响。方法:采用高效液相色谱法,分别考察了丹参饮片在不同加热时间、p H及反应时间下的丹参酚酸类成分峰面积变化规律。结果:在加热的6 h内,丹酚酸B在受热30 min峰面积最大,随后丹酚酸B开始发生降解,丹参素、原儿茶醛、丹酚酸A是终产物。丹酚酸A进一步在碱性条件下又发生降解,生成丹酚酸C和异丹酚酸C一对同分异体。结论:揭示了丹参在受热、p H条件下中丹酚酸类成分的转化规律,为丹参在中药制剂生产和临床应用中提供理论基础。Objective： To study the regularity of extraction time, pH of the phenolic acids in Salviae Miltiorrhizae Radix et Rhizoma. Method： Respectively investigates the Salviae Miltiorrhizae Radix et Rhizoma at different heating time, pH, and the reaction time of phenolic acids peak area change rule by High-performance liquid chromatography. Result： The content of salvianolic acid B was increasing and reached the maximum at 30 rain, but it decreased from 1 to 6 h. Tanshinol, protocatechuic aldehyde, salvianolic acid A is the final product. Salvianolie acid A could be converted into Salvianolic acid C and iso-salvianolic acid C by alkaline hydolysis. Conclusion： Reveals transformation of phenolic acids under heating, pH conditions, providing theoretical support in future Chinese medicine production and clinical applications of Salviae Miltiorrhizae Radix et Rhizoma.

关 键 词：丹参 丹参素 丹酚酸B 丹酚酸A 转化关系 

分 类 号：R284.1[医药卫生—中药学]