PGF_(2α)诱导的早期反应基因参与黄体退化的研究进展  

The Research Progress of PGF_(2α) Induced-Early Response Genes Involved in Luteal Regression

作　　者：茆达干[1] 郭南南[1] 邝美倩 

机构地区：[1]南京农业大学动物科技学院,南京210095

出　　处：《生物技术通报》2016年第2期30-37,共8页Biotechnology Bulletin

基　　金：中央高校基本科研业务费专项资金

摘　　要：哺乳动物卵巢黄体的存留对母畜生殖活动具有重要的作用。前列腺素F2α(PGF2α)是哺乳动物的主要溶黄体因子,通过与其受体结合,激活一系列早期反应基因,进而诱导黄体的功能性(孕酮水平下降)和结构性退化(细胞程序性死亡)。虽然PGF2α已被广泛应用于动物的同期发情、分娩控制和繁殖障碍治疗等方面,但其溶解黄体的分子机制尚未完全明确。综述了PGF2α受体及其诱导的早期反应基因参与卵巢黄体退化的研究进展,旨在为进一步研究PGF2α诱导黄体退化的分子机制提供理论依据。The remaining mammalian corpus luteum plays an important role in female reproductive activities. Prostaglandin F2 alpha（PGF2 alpha）, as a main luteolytic factor of the corpus luteum, through binding to its receptor, activates series of early response genes and induces luteal functional（a decrease in the level of progesterone）and structural degradation（programmed cell death）. Although PGF2αhas been widely used in the control of animal synchronization, delivery control and reproductive barrier, the molecular mechanism in the luteal regression is not yet clear. In this review, the advanced progress of PGF2α receptor and its induced early response genes in ovarian luteal regression is summarized, which provides a theoretical basis to study the molecular mechanism of PGF2α-induced luteal regression.

关 键 词：PGF2Α 早期反应基因 黄体退化 

分 类 号：S814[农业科学—畜牧学]