脂质体制剂学稳定性的研究技术与方法  

Techniques and methods evaluation on pharmaceutical stability of liposomes

作　　者：黄梓源 孙玉琦[1] 胡海洋[1] 庄蕊[1] 徐琪[1] 陈大为[1] 

机构地区：[1]沈阳药科大学药学院,辽宁沈阳110016

出　　处：《药学学报》2016年第3期356-361,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81102400)

摘　　要：脂质体作为一种药物载体,在体外易发生聚集融合和药物泄露,在体内易被降解和消除,其不稳定性限制了进一步应用和发展,因此采用合适的研究技术与方法,对有效评价脂质体的制剂学稳定性十分重要。本文根据脂质体稳定性影响因素和研究策略的不同,从物理、化学和生物稳定性3个方面,对近年来脂质体研究中制剂学稳定性的考察方法进行综述,可为脂质体制剂建立合适的稳定性考察体系,从而更好地发挥脂质体的应用价值与治疗优势。Liposomes as a drug carrier is easy to form aggregation and cause drug leakage in vitro. In addition, the degradation and elimination in vivo happens frequently to reduce its delivery activity. Development and application of liposomes are restricted by the instability. The appropriate techniques and methods are great important in the study of pharmaceutical stability of liposomes. In this paper, the techniques and methods are reviewed on pharmaceutical stability evaluation of liposomes, which was done from physical, chemical and biological stability for the difference in stability of liposomes. The research strategies for establishing the stability evaluation system and improving the value of liposomes have been discussed to make full therapeutic advantage of it.

关 键 词：脂质体 制剂学 稳定性 

分 类 号：R94[医药卫生—药剂学]