磷酸甘油酸变位酶5与坏死样凋亡  

Phosphoglycerate mutase 5 and necroptosis

作　　者：佘浪 彭军[1] 

机构地区：[1]中南大学药学院药理学系,湖南长沙410078

出　　处：《中国病理生理杂志》2016年第2期377-380,共4页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.91439104;No.81373409)

摘　　要：多年来人们认为细胞死亡方式主要包括坏死和凋亡。坏死是不受特定调控的被动死亡方式，表现为细胞器肿胀，细胞膜破裂，内容物渗出，有炎症反应[1]，而凋亡则是由细胞内胱天蛋白酶（caspase）调控的一种主动死亡方式，因caspase激活导致细胞内底物裂解，破坏胞膜囊泡形成凋亡小体，死亡过程中无内容物渗出，不引起炎症反应[2]。Necroptosis, or programmed cell death, is a type of cell death with a controllable death signaling pathway and the morphological features similar to necrosis. It is mainly mediated by death receptors or pathogen pattern re- cognition receptors. Among them, tumor necrosis factor receptor 1 （ TNFR1 ） -mediated necroptosis is the most well-studied one. Receptor-interacting protein kinase 1 （ RIPK1 ） and receptor-interacting protein kinase 3 （ RIPK3 ） are the 2 key kina- ses involved in the formation of complex I ＆ II and necrosome in the process of necroptosis. Phosphoglycerate mutase 5 （ PGAM5 ） , a member of phosphoglycerate mutase gene family, lacks PGAM activity and possesses the phosphatase activi- ty. PGAM5 is anchored in the mitochondrial membrane and is also called mitochondrial phosphoglycerate mutase 5. It has been shown that PGAM5 involves in the formation of necrosome during neeroptosis and it is able to accelerate the fission of mitochondria by dephosphorylation of dynamin-related protein 1 （ DRP1 ）, thus promoting cell necroptosis.

关 键 词：坏死样凋亡 磷酸甘油酸变位酶5 发动蛋白相关蛋白1 线粒体分裂 磷酸酶 

分 类 号：R363[医药卫生—病理学]