四氧化三铁纳米团簇的表面修饰及生物毒性研究  

Surface Modification and Biological Toxicity Study of Iron Oxide Nanoclusters

作　　者：杨筱筱 刘文宝[1] 张潇予[1] 柳瑞翠[1] 刘子全[1] 刘言周 姜付义[1] 

机构地区：[1]烟台大学环境与材料工程学院,烟台264005

出　　处：《人工晶体学报》2016年第2期551-557,共7页Journal of Synthetic Crystals

基　　金：国家自然科学基金(51272223)

摘　　要：采用微波辅助溶剂热法制备了四氧化三铁(Fe3O4)纳米团簇。为了改善团簇的稳定性,用改进的Stber法,在Fe3O4团簇的表面包覆一层氧化硅(SiO2),成功制备出核-壳结构的Fe3O4@SiO2粒子。用透射电镜(TEM)、X射线衍射仪(XRD)、纳米粒度仪、Zeta电位、振动样品磁强计(VSM)、MTT比色法等测试手段,对样品的形貌、结构、粒径分布、胶体稳定性、磁学性质及生物毒性进行了研究,结果表明:所制备的Fe3O4纳米团簇平均尺寸约为60nm,尺寸均匀,在室温下表现出超顺磁性。包覆后的核-壳结构Fe3O4@SiO2粒子平均尺寸约为150nm,具有良好的水分散性和胶体稳定性,包覆前后的样品均具有低的生物毒性。Nano-Fe3O4 clusters were prepared by microwave-assisted solvothermal method. In order to improve the stability of clusters,silica was coated on surface of the clusters to form Fe3O4@ SiO2core-shell particles by modified Stber method. The morphology, structure, particle size distribution, colloid stability,magnetic properties and toxicity of the products were characterized by Transmission electron microscope（ TEM）,X-ray powder diffraction（ XRD）,Nano particle sizer,Zeta potential,Vibrating sample magnetometer（ VSM）,MTT assay and other means. The results indicate that as-prepared iron oxide clusters have a average size of 60 nm. It exhibits superparamagnetism at room temperature. The Fe3O4@SiO2core-shell particles have a average size of 150 nm; with good water dispersibility and colloidal stability. The Fe3O4 clusters and Fe3O4@SiO2core-shell particles have low toxicity.

关 键 词：微波辅助溶剂热法 纳米氧化铁团簇 Stber法 核-壳结构 超顺磁性 

分 类 号：TQ138[化学工程—无机化工]