丹参多酚酸盐对急性左心衰疗效的随机对照研究  被引量:8

Effect of salvianolate on acute heart failure:a randomized controlled trail

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作  者:王毅[1] 吴龙飞[1] 刘芙蓉[1] 李林[1] 杨庆[2] 

机构地区:[1]巴中市中心医院心血管内科,四川巴中636000 [2]四川大学华西医院心内科,成都610041

出  处:《实用药物与临床》2016年第2期169-171,共3页Practical Pharmacy and Clinical Remedies

基  金:四川省医学会"施慧达"科研课题(SHD14-13)

摘  要:目的探讨丹参多酚酸盐对急性左心衰(AHF)的临床疗效。方法选择2013年9月至2015年3月我院心血管内科住院的126例AHF患者,随机分为治疗组(70例)和对照组(56例)。两组的治疗均按AHF指南进行,治疗组在指南治疗基础上加用丹参多酚酸盐静脉滴注,200 mg/d,疗程14d。比较两组住院死亡率、住院时间及不良反应发生率。在治疗前和治疗第14天进行血清B型脑钠肽(BNP)和左室射血分数(LVEF)检测。结果两组死亡率比较差异无统计学意义(P=0.838)。治疗组住院天数中位数低于对照组(7d vs.9 d,P=0.030)。治疗14 d后,治疗组血清BNP水平明显低于对照组,LVEF高于对照组,差异有统计学意义(P<0.05)。结论丹参多酚酸盐不能降低AHF患者住院死亡率,但能够改善心功能,缩短住院时间。Objective To assess the effects of salvianolate on acute heart failure(AHF).Methods Patients with identified AHF from September 2013 to March 2015 were enrolled in the study,and they were randomized into treatment group(n = 70) and control group(n = 56).Guideline directed medical therapy were performed in both group.Treatment group was added with salvianlate 200 mL intravenous infusion once daily for 14 d.The in-hospital mortality,length of stay and incidence of adverse reaction were compared between the 2 groups.The left ventricular ejection farction(LVEF),serum level of amino-N-terminal pro-plasma brain natriuretic peptide(NT-proBNP) of the two groups were recorded before and after treatment.Results There was no significant difference in in-hospital mortality between the two groups(P =0.838).The median hospital stay in treatment group,was shorter than that of control group(7 d vs.9 d,P=0.030).Compared with control group,the serum level of NT-proBNP in treatment group was lower,and the LVEF at 14 d after treatment was higher(P 〈0.05).Conclusion Salvianolate could not reduce the inhospital mortality of patients with AHF,but it can improve the heart function,shorten the length of hospitalization.

关 键 词:丹参多酚酸盐 急性左心衰 左室射血分数 脑钠肽 

分 类 号:R541.6[医药卫生—心血管疾病]

 

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