吲达帕胺凝胶骨架缓释片的处方工艺研究  

Study on prescription process of indapamide gel-matrix sustained-release tablets

作　　者：刘莉[1] 卢奕璇 朱萌 

机构地区：[1]中国医科大学附属盛京医院药学部,沈阳110004 [2]沈阳药大制剂新技术有限公司,沈阳110015

出　　处：《实用药物与临床》2016年第2期216-219,共4页Practical Pharmacy and Clinical Remedies

摘　　要：目的制备可以在体内缓慢释放、发挥疗效的凝胶骨架片。方法以体外释放度的测定为考察指标,用单因素考察法对填充剂、骨架材料和干粘合剂进行筛选和优化。结果通过对主要辅料的筛选和优化得到最终处方,其中MCC占32.4%,HPMC K4M占25%,HPMC K100M占12%。结论所制备的缓释片外观良好,体外释放行为符合要求。Objective To prepare the indapamide gel-matrix sustained-release tablets which can release slowly and steadily in vivo.Methods The matrix,fillers and dry binders were screened and optimized by single-factor test method with releasing degree in vitro as an indicator.Results The proportion of the main excipients in the final formulation was presented as follows：MCC 32.4%,HPMC K4 M 25%,HPMC K100 M 12%.Conclusion The prepared tablets have good appearance and release behavior in vitro.

关 键 词：吲达帕胺 缓释 制备工艺 溶出度 

分 类 号：R943[医药卫生—药剂学]