弓形虫感染治疗方法的研究进展  

Research progress in the treating methods of Toxoplasma gondii infection

作　　者：王大为[1] 郭晓改 司海洋[1] 穆名扬 李红魁[3] 李德臣 张国新[1] 袁高明[1] 邢蒙恩 杨娜[1] 

机构地区：[1]沈阳农业大学畜牧兽医学院,沈阳110866 [2]辽宁省农业经济学校,辽宁锦州121001 [3]辽宁省动物疫病预防控制中心,沈阳110164 [4]本溪市动物疫病预防控制中心,辽宁本溪117000

出　　处：《黑龙江畜牧兽医》2016年第3期54-57,61,共5页Heilongjiang Animal Science And veterinary Medicine

基　　金：国家自然科学基金青年科学基金项目(31201894);中国博士后科学基金面上项目(2014M561252)

摘　　要：弓形虫病是一种人畜共患寄生虫病,全球有1/3~1/2的人感染该疾病。弓形虫感染的临床表现各不相同,这种差异取决于宿主基因、寄生虫基因、宿主免疫状态、感染量及感染时寄生虫发育状态,这些因素仅是临床症状差异的部分原因。一些急性感染（如在婴儿期和胎儿期感染,大龄儿童、成人或者免疫功能低下者的严重感染）,如治疗及时,可被有效治愈。妊娠期孕妇要进行血清学检测来诊断该病,目的是为了便于在胎儿期和婴儿期进行治疗。一种无毒副作用可以消灭速殖子和缓殖子的药物和一种能防治该疾病的疫苗是全人类未来的共同需要。Toxoplasmosis is a zoonotic parasitic disease, and 1/3 to 1/2 of all people worldwide have been infected with the disease. Clinical manifestations of Toxoplasma gondii infections vary depending on host gene, parasite gene, host immune status, the amount of infection, and the developmental state of parasite when infecting its host; however, these factors are due in part to differences in clinical symptoms. Some a- cute infections, such as infections in the fetal and infancy periods, severe infections in elder children, adults or immunocompromised persons, can be effectively cured when promptly treated. A serological testing in pregnant women should be conducted during gestation to diagnose toxo- plasmosis, in order to facilitate the treatment of toxoplasmosis in the fetal and infancy periods. A kind of drug without toxic side effects to elimi- nate Toxoplasma gondii tachyzoites and bradyzoites, and a kind of vaccine to prevent toxoplasmosis are mankind＇s common needs in the future.

关 键 词：弓形虫 治疗 药物 感染 叶酸 乙胺嘧啶 磺胺嘧啶 

分 类 号：S852.7[农业科学—基础兽医学] S855.99[农业科学—兽医学]