辽宁省一般人群血和尿中锰水平研究  

Manganese levels in blood and urine of general population and their distribution features in Liaoning Province

作　　者：王凯[1] 魏明至 郑晓梅[1] 张瑶瑶[1] 庞妍[1] 何杨[1] 潘亚娟[2] 郑玉新[2] 闫慧芳[2] 田昊渊[2] 张蕴丽[3] 张云江 彭珊茁[1] 

机构地区：[1]沈阳市劳动卫生职业病研究所,辽宁沈阳110024 [2]中国疾病预防控制中心职业卫生与中毒控制所,北京100050 [3]辽宁医学院,辽宁锦州121001 [4]丹东市卫生监督所,辽宁丹东118002

出　　处：《中国工业医学杂志》2016年第1期12-15,共4页Chinese Journal of Industrial Medicine

基　　金：卫生部行业科研专项(200802020);国家科技支撑计划(2006BAI06B02);沈阳市科学计划项目(1091165-9-00)

摘　　要：目的调查辽宁省一般人群血和尿中锰水平,分析其人群分布特点。方法将辽宁省划分为东、中、西部地区,采用多阶段分层整群随机抽样的方法,于2009—2010年从东、中、西部三个地区抽取了3个城市的2105名对象进行问卷调查,并采集血液和尿液样品。用电感耦合等离子体质谱法对血样和尿样进行锰含量的检测,通过统计分析研究一般人群血和尿中锰的分布水平。结果辽宁省一般人群血锰几何均数为6.64μg/L,男性和女性血锰几何均数分别为6.08μg/L、7.07μg/L、(Z=-3.97,P<0.01);尿锰几何均数为0.49μg/L,男性和女性尿锰几何均数分别为0.53μg/L、0.46μg/L(Z=-1.70,P>0.05)。结论辽宁省一般人群血中锰水平存在性别及地区差异;尿中锰水平存在地区差异,而性别差异无统计学意义。Objective To survey the manganese（ Mn） levels in blood and urine among general population in Liaoning Province,and analyze their distribution features. Methods 2105 healthy persons were recruited from 3 cities located at eastern, central and western regions in Liaoning Province, respectively from 2009 to 2010. The general information was collected by questionnaire,blood and urine samples were collected at the same time. The Mn levels of blood and urine samples were detected by inductively coupled plasma mass spectrometry（ ICP-MS）,and its distribution features in blood and urine were analyzed by statistics method. Results It was showed that the geometric mean（ GM） of Mn in blood of the general population in Liaoning Province was 6. 64 μg / L,the GM of blood Mn among males and females were 6. 08 μg / L and 7. 07 μg / L,respectively（ Z =-3. 97,P〈0. 01）; while the GM of Mn in urine was 0. 49 μg / L,the GM of urine Mn among males and females were separately 0. 53 μg / L and 0. 46 μg / L,respectively（ Z =-1. 70,P〉0. 05）. Conclusion There are some gender and regional differences in serum manganese level in the general population of Liaoning Province,and there is regional differences found in urine Mn level.

关 键 词：锰 血液 尿液 电感耦合等离子体质谱 

分 类 号：R446.1[医药卫生—诊断学] O614.711[医药卫生—临床医学]