辽宁省一般人群血和尿中镉水平研究  

Levels and their influencing factors of cadmium in whole blood and urine among general population in Liaoning Province

作　　者：田昊渊[1] 阎波[2] 庞妍[2] 魏明至 王凯[2] 郑晓梅[2] 张瑶瑶[2] 何杨[2] 张蕴丽[3] 张云江[4] 丁春光[1] 闫慧芳[1] 郑玉新[1] 彭珊茁[2] 

机构地区：[1]中国疾病预防控制中心职业卫生与中毒控制所,北京100050 [2]沈阳市劳动卫生职业病研究所,辽宁沈阳110024 [3]辽宁医学院,辽宁锦州121001 [4]丹东市疾病预防控制中心,辽宁丹东118002

出　　处：《中国工业医学杂志》2016年第1期15-19,共5页Chinese Journal of Industrial Medicine

基　　金：卫生部行业科研专项(200802020);国家科技支撑计划(2006BAI06B02);沈阳市科学计划项目(1091165-9-00)

摘　　要：目的调查辽宁省一般人群血和尿中镉水平,分析其分布特点。方法采用整群随机抽样方法,2009—2010年在辽宁省东部、西部和中部抽取2105名6~60岁人群为调查对象,分别采集血液和尿液样品。应用电感耦合等离子体质谱法检测血和尿液中镉水平,并分析年龄、性别和区域对血和尿中镉水平的影响。结果辽宁省一般人群全血中镉的几何均数为0.45μg/L;男性和女性分别为0.58、0.35μg/L（Z=-6.32,P〈0.01）;东、中、西部人群分别为0.41、0.31和0.77μg/L（χ2=160.63,P〈0.01）;吸烟和不吸烟人群分别为3.7、0.31μg/L（Z=-20.95,P〈0.01）;饮酒和不饮酒人群分别为2.25、0.36μg/L（Z=-13.52,P〈0.01）。一般人群尿镉几何均数为0.44μg/L;男性和女性分别为0.46、0.43μg/L（Z=-1.88,P〉0.05）;东、中、西部人群分别为0.38、0.40和0.56μg/L（χ2=61.72,P〈0.01）;吸烟和不吸烟人群分别为0.60、0.41μg/L（Z=-5.82,P〈0.01）;饮酒和不饮酒人群分别为0.64、0.41μg/L（Z=-5.73,P〈0.01）。结论辽宁省一般人群血镉和尿镉水平存在性别及地区差异,并与吸烟和饮酒有关。Objective To survey the levels of cadmium（ Cd） in blood and urine among general population in Liaoning Province and their distribution features. Methods A total of 2105 subjects of general population aged 6—60 years from eastern,central and western regions of Liaoning Province were recruited from 2009 to 2010 by cluster random sampling method. The questionnaire survey was used to collect the information concerned living environment and health conditions,their blood and urine samples were collected for Cd detection using inductively coupled plasma mass pectrometry and their distribution characteristics among the groups with different ages,genders,living areas and life habits were analyzed as well. Results It was showed that among the general population in Liaoning Province,the geometric mean（ GM） of blood Cd was 0. 45 μg / L; GM of blood Cd in male and female were 0. 58 and 0. 35 μg / L（ Z =-6. 32,P〈0. 01）,respectively GM from eastern,central and western regions of Liaoning Province were 0. 41、0. 31 and 0. 77 μg / L（ χ2= 160. 63,P〈0. 01）,respectively; GM of blood Cd in smokers and non-smokers were 3. 7 and 0. 31 μg / L（ Z =- 20. 95,P 〈0. 01）,respectively; GM of blood Cd in drinkers and non-drinkers were 2. 25 and 0. 36 μg / L（ Z =-13. 52,P〈0. 01）,respectively; meanwhile the GM of urine Cd of whole population was 0. 44μg / L; GM of urine Cd in male and female groups were 0. 46 and 0. 43 μg / L（ Z =-1. 88,P〉0. 05）,respectively; the values from eastern,central and western regions were 0. 38、0. 40 and 0. 56 μg / L（ χ2= 61. 72,P 〈0. 01）,respectively; the levels in smokers and non-smokers were 0. 60 and 0. 41 μg / L（ Z =- 5. 82,P〈0. 01）,respectively; and the levels in drinkers and non-drinkers were 0. 64 and 0. 41 μg / L（ Z =- 5. 73,P〈 0. 01）,respectively. Conclusion The results suggested that there were some differences in blood or urine Cd levels among general population with different genders and living regions in Liaoning Province,which might

关 键 词：镉 血液 尿 横断面调查 电感耦合等离子体质谱 

分 类 号：R446.1[医药卫生—诊断学] O614.242[医药卫生—临床医学]