辽宁省一般人群尿中2,5-己二酮水平研究  

2, 5-Hexanedione levels in urine of general population in Liaoning Province

作　　者：郑晓梅[1] 王凯[1] 魏明至 张瑶瑶[1] 庞妍[1] 何杨[1] 潘亚娟[2] 郑玉新[2] 闫慧芳[2] 田昊渊[2] 张蕴丽[3] 张云江 彭珊茁[1] 

机构地区：[1]沈阳市劳动卫生职业病研究所,辽宁沈阳110024 [2]中国疾病预防控制中心职业卫生与中毒控制所,北京100050 [3]辽宁医学院,辽宁锦州114000 [4]丹东市卫生监督所,辽宁丹东118002

出　　处：《中国工业医学杂志》2016年第1期30-32,共3页Chinese Journal of Industrial Medicine

基　　金：卫生部行业科研专项(200802020);国家科技支撑计划(2006BAI06B02);沈阳市科学计划项目(1091165-9-00)

摘　　要：目的调查辽宁省一般人群尿中2,5-己二酮水平,分析其人群分布特点。方法将辽宁省划分为东、中、西部地区,采用多阶段分层整群随机抽样的方法,于2009—2010年从东、中、西部三个地区抽取1373名对象进行问卷调查,并采集尿液样品,采用气相色谱-离子阱二级质谱法对尿中2,5-己二酮的含量进行检测,统计分析一般人群尿中2,5-己二酮的分布水平。结果辽宁省一般人群尿中2,5-己二酮几何均数为0.18μg/L,男性和女性尿中2,5-己二酮几何均数分别为0.19μg/L、0.18μg/L(Z=-2.87,P<0.01)。结论辽宁省一般人群尿中2,5-己二酮水平存在性别及地区差异。Objective To survey the 2, 5-hexanedione levels in urine of general population in Liaoning Province,and analyze their prevalent distribution features. Methods 1373 healthy persons were recruited from 3 cities located at eastern,central and western regions in Liaoning Province,respectively from 2009 to 2010. The general information were investigated by questionnaire and urine samples were collected at the same time. The 2, 5-hexanedione levels of urine samples were detected by gas chromatography-ion trap tandem mass spectrometry（ GC-IT-MS / MS）,and the 2, 5-hexanedione distribution in urine among groups of population were analyzed by statistics method. Results It is showed that the geometric mean（ GM） of 2, 5-hexanedione concentration in urine among the general population of Liaoning Province was 0. 18 μg / L. The 2, 5-hexanedione concentration in urine among males and females were 0. 19 μg / L and 0. 18 μg / L（ Z =- 2. 87,P〈 0. 01）,respectively. Conclusion The result suggested that there are gender and regional differences of 2, 5-hexanedione level in urine of the general population in Liaoning Province.

关 键 词：2 5-己二酮 尿液 气相色谱-离子阱二级质谱 

分 类 号：R446.1[医药卫生—诊断学] O623.524[医药卫生—临床医学]