组织工程技术在食管缺损修复重建中的研究进展  

RESEARCH PROGRESS OF TISSUE ENGINEERING TECHNIQUE IN ESOPHAGEAL DEFECT REPAIR AND RECONSTRUCTION

作　　者：侯楠[1] 马瑞娜[2] 

机构地区：[1]成都医学院第一附属医院耳鼻咽喉头颈外科,成都610500 [2]第四军医大学唐都医院耳鼻咽喉头颈外科

出　　处：《中国修复重建外科杂志》2016年第3期323-327,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：四川省科技支撑计划项目(14Z016)~~

摘　　要：目的对组织工程技术在食管缺损修复重建方面的研究进展作一综述。方法广泛查阅近年来组织工程技术在食管缺损修复重建方面的相关文献,对构建组织工程食管所需的支架材料、种子细胞及方法等进行综述。结果大量基础研究和临床应用表明,组织工程食管能修复食管黏膜缺损及长段食管缺损,其修复效果接近自体组织结构及功能,但目前用于构建组织工程食管的支架材料及种子细胞众多,尚无统一制备技术,组织工程技术进入临床研究仍有一定差距。结论组织工程技术为临床食管修复缺损重建提供了新的思路和依据,但用于临床有待进一步研究。Objective To review the research progress of the tissue engineering technique in the esophageal defect repair and reconstruction. Methods The recently published clinical and experimental literature at home and abroad on the scaffold materials and the seeding cells used in the tissue engineered esophageal reconstruction was consulted and summarized. Results A large number of basic researches and clinical applications show that the effect of the tissue engineered esophagus is close to the autologous structure and function of the esophagus and it could be used for the repair of the esophageal defect. However, those techniques have a long distance from the clinical application and need an acknowledged rule of technology. Conclusion Tissue engineering technique could provide an innovative theory for the esophageal defect reconstruction, but its clinical application need further research.

关 键 词：组织工程食管 功能重建 支架材料 种子细胞 

分 类 号：R318.08[医药卫生—生物医学工程]