微通道中细胞转动对其化学微环境的影响  

Influence of Cell Rotation on Its Chemical Microenvironment Inmicrochannels

作　　者：李沛晔 都晓慧 胡延东[1] 赵社戌[1] 

机构地区：[1]上海交通大学船舶海洋与建筑工程学院,上海200240

出　　处：《上海交通大学学报》2016年第2期283-287,共5页Journal of Shanghai Jiaotong University

基　　金：国家自然科学基金项目(51206108);教育部博士点基金项目(20120073120016)资助

摘　　要：采用FLUENT软件模拟了T型引物梯度产生器中的细胞转动过程,分析了细胞转动的线速度、方向和细胞尺寸对其化学微环境的影响.结果表明:在细胞转动的过程中,由于产生额外的引物输运,使其周围引物浓度在一定时间内发生变化,但最终达到稳态;顺时针与逆时针转动的细胞对微环境的搅动效果相反;增加细胞转动的线速度,可以增强其对微环境的搅动效果,但将导致趋化偏转角增大而使得趋化动力减小;细胞尺寸对于细胞趋化偏转角的影响较小,但对其趋化动力的影响较大.The influence of cell rotation on its chemical microenvironment was investigated by performing systematic numerical simulations.The influences of the line speed,rotational direction and the cell size were investigated.The results show that when a till cell starts rotating,the ambient concentration field and the flow field keep changing until they reach steady states.Different cell rotational directions lead to dramatic changes on the disturbing effect;and the peripheral speed of the cell enhances the stirring effect and hence decreases the apparent chemotactic effect.This paper contributes to the development of chemotactic experimental platform and quantitative measurement methodology.

关 键 词：微通道 微流体 细胞趋化 细胞转动 浓度梯度 

分 类 号：O363.2[理学—流体力学]