CUR-CAP/PLGA纳米静电纺丝纤维膜的制备和活性研究  

Synthesis and bioactivity investigation of CUR-CAP/PLGA electrostatic spinning nano-fiber membrance

作　　者：吴乃鹏[1] 田大庚 宋佳[1] 王春艳[1] 

机构地区：[1]吉林大学公共卫生学院,吉林长春130021 [2]吉林省特恩斯制衣有限公司,吉林长春137100

出　　处：《分子科学学报》2016年第1期60-64,共5页Journal of Molecular Science

基　　金：吉林省科技厅科技发展计划科技支撑项目(20110940);吉林省科技厅科技发展计划国际合作项目(20130413059GH);第50批中国博士后科学基金面上资助项目(2011M500600)

摘　　要：采用静电纺丝的方法制备了不同质量分数的CUR-CAP/PLGA复合静电纺丝纤维膜,并通过扫描电子显微镜、红外光谱、单晶X射线衍射进行表征,并用四唑盐MTT比色法测定其对成纤维细胞增殖的影响.表征结果表明:所合成的复合静电纺丝纤维膜的直径具有纳米结构,复合薄膜中,3种物质很好的混合在一起,没有发生化学键的结合.细胞实验检测结果显示,CUR-CAP/PLGA复合膜有助于细胞在其表面的生长及增殖,当姜黄素的质量分数为3%、氯霉素的质量分数为1%时效果最佳.The electrostatic spinning nano-fiber membrance of curcumin（CUR）-chloramphenicol CAP/poly lactide-co-glycolide（PLGA） were prepared by electrospinning method. The structures of nano-composite are characterized by means of scanning electron microscopy（SEM）, X-ray diffraction（XRD） and infrared spectroscopy（IR）. The cell compatibility was determined by MTT colorimetric assay. Characterization results show that the synthese of compound with electrostatic spinning fiber membrane has nano structure with these 3 materials mixing together. The combination of chemical bond didn＇t occur in the 3 materials. The cell culture showed that nano-composite is good for the cell＇s growth and proliferation when the content of curcumin and chloramphenicol was 3% and 1%, respectively.

关 键 词：静电纺丝 聚乳酸-乙醇酸 姜黄素 氯霉素 生物活性 

分 类 号：O631[理学—高分子化学]