氯胺酮滥用危害的研究进展  

DAMAGES OF KETAMINE ABUSE: A REVIEW

作　　者：杨晶金[1] 梁勇[1] 胡诺恩 周展鸿 邓康齐 姚大卫[2] 

机构地区：[1]台州学院医学院,台州 [2]香港中文大学中医学院,中国香港

出　　处：《中国药物依赖性杂志》2016年第1期37-41,共5页Chinese Journal of Drug Dependence

摘　　要：氯胺酮是苯环己哌啶(Phencyclidine,PCP)的衍生物,是非竞争性N-甲基-D-天门冬氨酸(N-methyl-D-aspartate,NMDA)受体拮抗剂,是一种静脉全麻药,也是一种目前在青少年人群中广泛流行的毒品。氯胺酮具有中枢兴奋、中枢抑制、镇痛、抗焦虑、麻醉、致幻等作用,长期使用后可以导致神经系统、泌尿系统、消化系统、心血管系统的损害。Ketamine is a phencyclidine derivative,a noncompetitive N-methyl-D-aspartic acid（ NMDA） receptor antagonist,a kind of intravenous anesthetics,and also a commonly abused drug among the adolescent population.Ketamine has the effects of both central excitation and central inhibition.It also exhibits analgesic,anesthetic,anti-anxiety and hallucinogenic properties.It can cause a series of damages such as those on the nervous system,urinary system,digestive system and cardiovascular system upon long-term administration.

关 键 词：氯胺酮 非竞争性N-甲基-D-天门冬氨酸受体拮抗剂 认知能力 中枢神经系统 泌尿系统 消化系统 心血管系统 

分 类 号：R946[医药卫生—药剂学]