老年人糖尿病与睡眠呼吸暂停低通气综合征关系的研究  

Relationship between obstructive sleep apnea-hypopnea syndrome and diabetes mellitus in aged patients

作　　者：侯晓平[1] 缪京莉[1] 张婧[1] 王玉军[1] 陈艳芳[1] 马艳敏[1] 

机构地区：[1]解放军空军总医院,北京100142

出　　处：《现代中西医结合杂志》2016年第9期926-928,931,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的探讨糖尿病对老年阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的影响。方法对106例老年OSAHS患者的临床资料进行回顾性分析,以是否合并糖尿病分组比较睡眠呼吸紊乱事件和血氧水平,并以年龄分组进行亚组比较。结果合并糖尿病32例占30.1%。糖尿病组年龄、低通气指数(HI)均明显高于非糖尿病组(P均<0.05),阻塞性暂停时长/呼吸事件时长比值明显低于非糖尿病组(P<0.05),2组性别、所患基础疾病、OSAHS和低氧血症程度及睡眠时间、呼吸事件、呼吸事件时长、低通气时长/呼吸事件时长比值比较差异均无统计学意义(P均>0.05)。以年龄分组比较,<80岁糖尿病组低通气时长/呼吸事件时长比值明显高于非糖尿病组(P<0.05),呼吸暂停时长/呼吸事件时长比值和阻塞性暂停时长/呼吸事件时长比值均明显低于非糖尿病组(P均<0.05);≥80岁糖尿病组与非糖尿病组呼吸紊乱参数比较差异均无统计学意义(P均>0.05)。相关性分析显示,仅在≥80岁糖尿病组存在着与增龄相关的呼吸紊乱指数、呼吸暂停指数和HI增高(r=0.573,0.540,0.525,P均<0.05)。结论合并糖尿病的老年OSAHS患者睡眠呼吸紊乱较非糖尿病患者更为严重。Objective It is to investigate the influence of diabetes mellitus （DM） on obstructive sleep apnea-hypopnea syndrome （OSAHS） in aged patients. Methods The data of 106 cases of aged patients with OSAHS were retrospectively re- viewed. The patients were divided two groups according to whether they had DM or not. The parameters of sleep disordered breathing were compared and analyzed between groups and according to the ages. Results The patients of 32 cases （30.1% ） with DM. In DM group, the age and hypopnea index （HI） were significantly higher than that in non-DM group （ all P 〈 0.05 ） , and the value of obstructive apnea time （OAT）/ event time （ET） were markedly lower than that in non-DM group （P 〈 0.05） , there was no significant difference in gender, basic diseases, OSAHS and hypoxia degree, sleep time, respiratory e- vents, ET, the value of hypopnea time （HT）/ET between the both groups （all P 〉0.05）. In the patients less than 80 years old, the value of HT/ET in DM group was higher, and the value of apnea time （AT）/ET, OAT/ET were lower than that in non-DM group, there were significant difference （all P 〈0.05）. In the patients older than 80 years, there was no significant difference in these indexes between the the both groups （ all P 〉 0.05 ）. Correlation analysis showed that there was a signifi- cant positive relationship between age with respiratory disturbance index, apnea index, HI, respectively parameters of sleep disordered breathing only in more than 80 years old patients in DM group （ r = 0. 573, 0. 540, 0. 525, all P 〈 0.05 ）. Conclusion In aged patients with OSAHS, sleep disordered breathing is more serious in patients with DM than those without.

关 键 词：糖尿病 阻塞性睡眠呼吸暂停低通气综合征 老年人 

分 类 号：R332[医药卫生—人体生理学]