北京地区儿童青少年生活方式和社会-经济因素对瘦素脂联素比值的影响  

Influence of lifestyle and social-economic factors on leptin/adiponectin ratio among children and adolescents in Beijing

作　　者：李路娇 黎明[1] 阴津华[1] 徐璐[1] 王颖[1] 高珊[2] 米杰[3] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院内分泌科卫生与计划生育委员会内分泌重点实验室,100730 [2]首都医科大学附属朝阳医院京西院区内分泌科 [3]首都儿科研究所流行病学教研室

出　　处：《中华糖尿病杂志》2016年第2期75-80,共6页CHINESE JOURNAL OF DIABETES MELLITUS

基　　金：北京市科技计划重点项目（D111100000611001）;中国医学科学院NNDU糖尿病英才基金（2011A002）

摘　　要：目的探讨生活方式和社会-经济因素对儿童青少年瘦素脂联素比值（L／A）的影响。方法选取2004年启动的“北京地区营养转型期儿童成人慢病综合防治研究项目”中3385名北京地区儿童青少年代谢综合征研究队列的6—18岁儿童青少年为研究对象。酶联免疫吸附法测定血清瘦素（LEP）和脂联素（APN）水平。通过调查问卷收集儿童青少年生活方式和社会。经济因素相关数据。组间比较采用方差分析，采用多因素线性回归分析生活方式、社会经济因素与ⅣA相关性。结果（1）年龄、性别、青春发育和生活方式及社会．经济因素在uA五分位各组间存在显著差异（F值：2．9-58．7，均P〈0．05），且在L/A增高组，代谢紊乱程度明显加重（F值：6．9-999．9，均P〈0．05）；（2）多因素线性回归提示运动、父亲受教育程度和睡眠时间与L／A独立负相关（偏回归系数分别为-0．129、-0．079、-0．060，标准化偏回归系数分别为-0．107、-0．065、-0．046），父亲无业、母亲教育程度、母亲无业和电视时间与叭独立正相关佩回归系数分别为0．504、0．156、0．396、0．047，标准化偏回归系数分别为0．068、0．122、0．073、0．042，均P〈0．05）。结论通过改善生活方式和社会经济状况可早期预防脂肪因子谱的紊乱从而避免代谢紊乱的发生。Objective To investigate the influence of lifestyle and social-economic factors on leptin/adiponectin ratio （L/A） among children and adolescents in Beijing. Methods Total of 3 385 children and adolescents between 6 and 18 years of age were selected from the subjects who were recruited in survey which was conducted by Beijing Children and Adolescent Metabolism Syndrom（BCAMS） cohort study in 2004. Enzyme-linked immunosorbent assay was used to determine serum leptin （LEP） and adiponectin （APN） levels. Self-reported information on lifestyle and social-economic factors were collected by questionnaire. Results （1） The age, gender, Tanner stage, lifestyle and social-economic status were different in LEP/APN ratio （L/P） quintile groups（F value： 2.9-58.7,all P〈0.05）, the metabolic disorder status was more seriously in the high L/A group than the low L/A group （F value： 6.9-999.9,all P〈0.05）.（2）Muhiple linear regression showed that the physical activity, father＇ s education level and sleep duration were independent negative correlated with IJA （unstandardized coefficients were -0.129,-0.079,-0.060respectively and standardized coefficients were- 0.107,- 0.065,- 0.046, respectively, all P〈0.05） and the unemployed father, mother＇ s education level, unemployed mother and TV- watching time were independent positive with L/A （unstandardized coefficients were 0.504, 0.156, 0.396, 0.047 respectively and standardized coefficients were 0.068, 0.122, 0.073, 0.042 respectively, all P〈0.05）. Conclusions We can optimize lifestyle and social- economic factors to improve the adipocytokines profile and prevent metabolic disorder status.

关 键 词：生活方式 瘦素脂联素比值 儿童青少年 社会-经济因素 

分 类 号：R725.8[医药卫生—儿科]