慢性阻塞性肺疾病患者超声心动图心脏功能特点分析  被引量:12

Cardiac function of patients with chronic obstructive pulmonary disease evaluated by echocardiography

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作  者:莫为春[1] 张志华[2] 王伟[1] 郑风雅 张熙[3] 申捷[4] 

机构地区:[1]上海市复旦大学附属金山医院急诊科,200540 [2]上海市复旦大学附属金山医院心脏超声室,200540 [3]上海市复旦大学附属金山医院肺功能科,200540 [4]上海市复旦大学附属金山医院重症监护室,200540

出  处:《中华全科医师杂志》2016年第2期130-134,共5页Chinese Journal of General Practitioners

基  金:上海市金山区卫生局资助项目(JSKJ-KTMS-201201)

摘  要:目的应用超声心动图评价不同分型慢性阻塞性肺疾病(COPD)患者的左、右心室功能。方法选取2011年1月1日至2013年12月31日就诊的COPD患者328例,依据慢性阻塞性肺疾病全球倡议(GOLD)分型的严重程度将COPD患者分为轻度、中度、重度和极重度4组,同时选取年龄、性别匹配的60名健康志愿者作为对照组进行研究。分别采用常规超声心动图、二维斑点追踪技术(2D—STE)测量并计算各COPD组患者及对照组志愿者左、右心室功能指标。结果重度、极重度组COPD患者左心室射血分数分别为(60.9±2.0)%和(59.4±2.8)%,低于对照组(t值分别为3.358、4.859)、轻度组(t值分别为5.247、6.641)和中度组(t值分别为3.280、4.863)COPD患者(均P〈0.01);极重度COPD组患者左房内径为(3.9±0.5)cm,较对照组、轻度、中度和重度组COPD患者扩大(t值分别为-2.407、-2.625、-2.071、-2.186,均P〈0.05);肺动脉收缩压为(39.7±11.5)mmHg(1mmHg:0.133kPa),较对照组、轻度、中度和重度组(t值分别为-6.277、-6.166、-5.298、-4.142,均P〈0.001)明显增高;右心室射血分数为(42.8±7.3)%,低于对照组、轻度、中度和重度组(t值分别为6.357、6.832、5.581、4.639,均P〈0.05);中度、重度和极重度组COPD患者右心室面积变化分数分别为(37.7±2.0)%、(35.5±3.2)%和(34.0±3.1)%,均低于对照组(t值分别为-4.616、-5.982、-7.195,均P〈0.05),并随着分级程度加重而降低。中度、重度和极重度COPD患者左心室整体纵向应变值分别为(-18.62±1.76)%、(-17.15±0.73)%和(-16.51±0.89)%,低于对照组(t值分别为-9.389、-15.494、-16.873,均P〈0.001);中度、重度和极重度COPD患者右心室整体纵向应变值分别为(-20.52±2.2Objective To evaluate the cardiac function in patients with chronic obstructive pulmonary disease (COPD) by using echocardiography. Methods Three hundred and twenty eight COPD patients and 60 age and gender-matched healthy subjects (control group ) were enrolled in the study. According to Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, patients were as classified as mild ( n = 102) , moderate ( n = 85 ) , severe ( n = 80) and very severe (61). All participants underwent conventional echocardiography and two dimensional-speckle tracking echocardiography (2D-STE) to assess cardiac function. Results The LVEF was reduced significantly, while the PASP was increased in severe and very severe COPD patients [(60.9±2.0)% and (59.4 ±2.8)%, t value: 3.358, 4.859 to normal controls, 5. 247, 6. 641 to mild, 3. 280, 4. 863 to moderate, respectively, all P 〈0. 001 ]. The LA size was dilated in very severe COPD patients [ (3.9 ±0. 5 ) cm, t value: - 2. 407, - 2. 625, - 2. 071, - 2. 186, P 〈 0. 05 ] , and the RVEF was significantly less than those of the other patients [ ( 42. 8 ± 7.3)% ,t value: 6.357, 6.832, 5.581, 4.639, P 〈0.05]. The fight ventricular FAC of moderate or severe COPD patients and the segmental and global LS of left and right ventricular in COPD patients were significantly lower than those in the normal controls, and which were gradually decreased as GOLD classification rising [ RVFAC, moderate : ( 37.7 ± 2. 0 ) % , severe : ( 35.5 ± 3.2 ) % , very severe : (34. 0 ± 3. 1) %, t value: - 4. 616, - 5. 982, - 7. 195, respectively; LSLVg, moderate : ( - 18.62 ± 1.76) %, severe: ( -17.15 ±0.73) %, very severe: ( -16.51 ±0.89) %, t value: -9.389, - 15. 494, - 16. 873, respectively; LSRVg, moderate: ( -20. 52 ±2. 27) % , severe: ( - 18.84 ± 1.38) % , very severe: ( - 16. 82 ± 1.10) % , t value: - 8.555, - 13. 595, - 18.499, respectively, all P 〈 0. 001 ]. Besides,

关 键 词:肺疾病 慢性阻塞性 心室功能 超声心动描记术 

分 类 号:R563.9[医药卫生—呼吸系统]

 

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