利福平致急性肾功能衰竭一例并文献复习  

Rifampin-induced acute renal failure： report of one case and review of literature

作　　者：高学松[1] 郑雪琴[2] 阿布力米提·买吐送 张瑞红[2] 段雪飞[1] 

机构地区：[1]首都医科大学附属北京地坛医院综合科,100015 [2]新疆维吾尔自治区和田地区人民医院感染科,848000

出　　处：《中华全科医师杂志》2016年第2期138-141,共4页Chinese Journal of General Practitioners

基　　金：北京市卫生系统高层次卫生技术人才培养项目（2014-3-093）

摘　　要：分析和田地区人民医院2014年收治的1例利福平导致急性肾功能衰竭（ARF）患者及国内万方医学数据库内近5年报道的21例类似患者的临床特点。本例患者既往有利福平用药史，再次服药后出现ARF，伴贫血、血小板计数减少，治疗好转后出院。文献报道中19例既往有VI服利福平用药史，停药治疗后19例患者肾功能恢复，1例进展至慢性肾功能衰竭，1例死亡。提示利福平导致ARF常见于再次用药者，用药过程中应严密观察，及时发现，早期治疗。A 61-year female patient with pulmonary tuberculosis and a history of rifampin administration was admitted on April 2014. After treatment with antibiotics and rifampin she presented acute renal failure （ARF） with anemia and thrombocytopenia. The patients received steroid treatment, made significant improvement and discharged. Literature searching showed that 21 cases with rifampin-induced ARF were reported in 5 years in China. Among 21 patients, 19 cases recovered after withdrawal of rifampin and proper treatment, 1 case progressed to chronic renal failure and 1 case died. We conclude that rifampin- induced ARF is not rare, especially in those rifampin re-exposure patients; and the clinical symptoms and renal function should be monitored closely when patients taking rifampin.

关 键 词：利福平 急性肾功能不全 

分 类 号：R692.5[医药卫生—泌尿科学]