冠心病患者高胆固醇血症与血浆血小板因子4及β-血小板球蛋白的关系  

Relationship of hypercholesterolemia with platelet factor 4 and β-thromboglobulin in the patients with coronary heart disease

作　　者：卢亚敏[1] 霍丽静[2] 张明明[2] 刘光霞[1] 陈芳[1] 

机构地区：[1]河北省人民医院核医学科,河北省石家庄市050051 [2]河北省人民医院检验科,河北省石家庄市050051

出　　处：《实用老年医学》2016年第2期108-110,共3页Practical Geriatrics

基　　金：河北省医学科学研究重点课题计划(ZD20140413)

摘　　要：目的探讨冠心病患者高胆固醇血症与血浆血小板因子4(PF4)、β-血小板球蛋白(β-TG)等分子水平的关系及意义。方法纳入冠心病患者160例,分为急性冠脉综合征(ACS)组64例以及稳定型心绞痛组(SAP组)96例,另选取同期健康体检者70例为对照组(CON组);按照总胆固醇(TC)水平把160例冠心病患者分为3组:(1)高胆固醇血症组(HTC组)42例,(2)边缘高胆固醇血症组(BTC组)51例,(3)胆固醇正常组(NOR组)67例。酶联免疫吸附法测定各组血浆PF4浓度和β-TG浓度水平,同期检测各组血脂指标,并对结果进行分析。结果 PF4、β-TG水平在CON组、SAP、ACS组间依次升高,且两两比较差异有统计学意义;PF4、β-TG水平在NOR组、BTC组、HTC组的水平也依次升高,且两两比较差异有统计学意义(P<0.05或P<0.01);TC水平与PF4、β-TG呈正相关(P<0.05或P<0.01),多元线性回归分析显示,TC水平是影响血清PF4、β-TG水平的独立因素。结论冠心病患者PF4、β-TG水平较正常组升高,胆固醇水平可能通过影响PF4、β-TG的水平促进冠心病的发生,且与冠心病病情程度相关。Objective To investigate the relationship of hypercholesterolemia with platelet factor 4（ PF4） and β-thromboglobulin（ β-TG） in the patients with coronary heart disease（ CHD）. Methods 160 patients with CHD were chosen and divided into 2 groups： ACS group（ 64 cases） and SAP group（ 96 cases）. Seventy healthy people were chosen as control group. The patients with CHD were divided into 3 groups according to the level of total cholesterol（ TC） ：（ 1）HTC group（ 42 cases,TC≥6. 22 mmol / L）;（ 2） BTC group（ 51 cases,5. 18 mmol / L 〈TC 〈6. 19 mmol / L）;（ 3） NOR group（ 67 cases,TC≤5. 18 mmol / L）. The levels of PF4 and β-TG were measured by the method of ELISA,and compared between the groups. Results The levels of PF4 and β-TG were highest in ACS group,followed by SAP group and CON group（ P〈0. 05 or P〈0. 01）; The levels of PF4 and β-TG were highest in HTC group,followed by BTC group and NOR group（ P〈0. 05 or P〈0. 01）. Stepwise multiple linear regression analysis showed that TC was an independent factor affecting PF4 and β-TG. Conclusions The levels of PF4 and β-TG are increased in the patients with CHD. TC might aggravate CHD by affecting the levels of PF4 and β-TG.

关 键 词：冠心病 高胆固醇血症 边缘高胆固醇血症 血小板因子4 Β-血小板球蛋白 

分 类 号：R589.2[医药卫生—内分泌]