老年正常高值血压人群中白细胞计数与其血压水平的关系  

Relationship between white blood cell count and blood pressure in old subjects with prehypertension

作　　者：王坤伟 杜培宜[1] 魏新萍 

机构地区：[1]同济大学附属天佑医院内分泌科,上海市200331 [2]闵行区古美社区卫生服务中心,上海市201102

出　　处：《实用老年医学》2016年第2期150-153,共4页Practical Geriatrics

摘　　要：目的探讨老年正常高值血压人群中白细胞（WBC）计数与其血压水平的相关性。方法入选上海市闵行区古美社区849例年龄≥60岁的体检者为研究对象。测量其身高、腰围（W）、臀围（H）、体质量和血压,检测外周血WBC计数、空腹血糖（FBG）和血脂。根据血压水平将其分为3组：正常血压组（〈120/80 mm Hg,n=257）、正常高值血压1组（120-129/80-84 mm Hg,n=265）、正常高值血压2组（130-139/85-89 mm Hg,n=327）。结果随着血压水平升高,WBC水平逐渐升高（P〈0.05）。Pearson相关分析显示,无论男性或女性,WBC计数与收缩压（SBP）、三酰甘油（TG）均呈正相关,与高密度脂蛋白胆固醇（HDL-C）呈负相关（P〈0.01）。Logistic回归分析显示,在校正年龄、性别、体质量、W、H、TG、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和体质量指数（BMI）后,正常高值血压2组发生WBC计数升高（WBC≥6.50×10^9/L）,是正常血压组的1.51倍（95%CI：1.01-2.25,P〈0.05）。多元线性回归分析显示,WBC计数是SBP及舒张压（DBP）升高的独立危险因素（B值分别为0.169、0.099,均P〈0.01）。结论老年正常高值血压人群中,WBC计数升高与其血压水平升高有关,且这种作用独立于其他多重危险因素。Objective To analyze the relationship between white blood cell count（ WBC） and blood pressure in old subjects with prehypertension. Methods This study enrolled 849 subjects undergoing health examinations aged 60 years or over from Gumei Community of Shanghai. The height,waist circumference（ W）,hip circumference（ H）,weight,blood pressure,white blood cell count,fasting blood glucose and blood lipid were measured. The subjects were classified into three groups according to the level of blood pressure, normal blood pressure group（ 120 / 80 mm Hg, n = 257）,prehypertension group 1（ 120 - 129 / 80 - 84 mm Hg,n = 265）,prehypertension group 2（ 130 - 139 / 85 - 89 mm Hg,n = 327）.Results White blood cell count increased with the increase of blood pressure（ P〈0. 05）. Pearson correlation analysis showed that WBC was positively related to systolic blood pressure（ SBP） and triglyceride（ TG）,but negatively correlated with high density lipoprotein cholesterol（ HDL-C） in men and women（ P〈0. 01）. Logistic regression analysis showed that the risk of elevated WBC in prehypertension group 2 was 1. 51 times（ 95% CI： 1. 01 - 2. 25,P〈0. 05） of that in normal blood pressure group after adjusting for age,gender,weight,W,H,TG,total cholesterol（ TC）,low density lipoprotein cholesterol（ LDL-C） and body mass index（ BMI）. Multiple line regression analysis showed that WBC was an independent factor of SBP and diastolic blood pressure（ DBP）（ B = 0. 169 and 0. 099,all P〈0. 01）. Conclusions In the subjects aged 60 years or over with prehypertension,elevated WBC count is independently associated with the increase of blood pressure.

关 键 词：老年人 正常高值血压 白细胞 

分 类 号：R331.1[医药卫生—人体生理学]