子宫颈微偏腺癌早期诊断的临床及病理特点分析  

A nalysis of clinical and pathologic characteristics of cervical minimal deviation adenocarcinoma in early diagnosis

作　　者：李剑[1] 

机构地区：[1]天津市中心妇产科医院妇瘤科,天津300100

出　　处：《中国城乡企业卫生》2016年第1期11-14,共4页Chinese Journal of Urban and Rural Enterprise Hygiene

摘　　要：子宫颈微偏腺癌是临床上极为少见的一种子宫颈高分化腺癌,据文献统计,其仅占宫颈腺癌的1%~3%,由于该类肿瘤组织形态与正常宫颈的内膜上皮和腺体极为相似,故其缺乏特异性的临床表现和妇科检查体征;部分患者可合并黑斑息肉综合征和卵巢黏液性囊腺瘤,极易误诊和漏诊。B超声检查提示宫颈明显增粗伴宫腔积液,强化M RI可提示宫颈明显增粗,可见宫腔有液体聚集,T：加权M RI多数病例可显示多囊性病灶或非囊性的细绒毛状改变,用阿利辛/高碘酸希夫（A B/PS C）染色,可以有助于鉴别子宫颈微偏腺癌和良性宫颈病变腺体细胞。免疫染色CEA,P5 3,Ki-67三项指标,在M D A均呈阳性或强阳性表达。本文综述子宫颈微偏腺癌的临床特点,特异性辅助检查及免疫组化等在早期诊断宫颈微偏腺癌中的意义。Cervical minimal deviation adenocarcinoma（MDA） is a rare and highly differentiated adenocarcinoma.According to the literature,it accounts for only 1%~3%.The morphology of the tumor tissue is similar to the normal cervical epithelium and glands,so it lacks specificity of the clinical manifestations and gynecological examination signs.Some patients were easily missed with Peutz Jegher＇s syndrome and ovarian mucinous cystadenoma.The ultrasonic examination showed that the cervix was obviously enlarged and uterine fluid.MRI also suggested that the cervix is obviously enlarged and uterine fluid.The weighted MRI can display polycystic lesions or non cystic changes of fine villi in majority cases AB/PSC staining can distinguish MDA and benign cervical lesion.The immunohistochemical analysis of CEA,P53,Ki-67 were positive or strongly positive in MDA.We review the clinical features,specificity assistant examination and immunohistochemical detection of MDA in early diagnosis.

关 键 词：子宫颈微偏腺癌 早期诊断 CEA P53 Ki-67检测 

分 类 号：R713.42[医药卫生—妇产科学]