Fe_3O_4磁性纳米粒子在生物医学领域的应用  

The Application of Fe_3O_4 Magnetic Nanoparticles in the Biomedical Field

作　　者：郭艳余[1] 任宽[1] 刘伟[1] 林丽[1] 

机构地区：[1]哈尔滨工业大学生命科学与技术学院,黑龙江哈尔滨150080

出　　处：《现代生物医学进展》2016年第3期574-576,503,共4页Progress in Modern Biomedicine

基　　金：国家自然科学基金项目(21273014)

摘　　要：Fe_3O_4磁性纳米粒子由于其良好的磁学性能,被广泛应用到了化学、生物、物理、环境保护等各个领域。尤其是在生物医学领域中的应用越来越受到研究者的关注。由于其所具有的优秀的超顺磁性性质,Fe_3O_4磁性纳米粒子可以作为造影剂,增强核磁共振成像的对比度和成像效果;也可以结合到纳米载药系统内用于药物的靶向输送;也可以包埋到蛋白内部用于蛋白的磁性分离;也可以用于基因治疗,提高靶细胞的转染效率;由于其在近红外光的作用下具有很好的光热转换效果,使温度升高,展现出的良好热疗效果,Fe_3O_4磁性纳米粒子又可以用于癌细胞的热疗。本文针对其在该领域中作为药物的靶向传递,蛋白的磁分离,核磁共振成像,热疗,以及基因治疗的载体等方面的研究应用进行了系统性的总结,阐述了Fe_3O_4磁性纳米粒子在生物医学领域中各种应用进展和优势。Fe_3O_4 magnetic nanoparticles have been widely applied to various fields because of its excellent magnetic properties.Especially in biomedical domain, the nanoparticles had attracted more and more attention. Because of the excellent superparamagnetic properties they have, Fe_3O_4 nanoparticles have been widely applied to various fields： It can be used as contrast agents, which will enhance the contrast and imaging effect of MRI and can be incorporated into the nano-targeted drug delivery systems for drug delivery. Besides, it can be embedded into the proteins for magnetic separation and can be used in gene therapy, which can raise the transfection efficiency of target cells. Meanwhile, it can be used for hyperthermia of cancer due to the good effect of light-heat conversion subjected to near-infared light, where the temperature rise, showing fine results. The objective of this review is to systematically summarized the applications of Fe_3O_4 magnetic nanoparticles in biomedical field as drug targeted delivery, protein magnetic separation, magnetic resonance imaging, hyperthermia, as well as gene therapy vectors, and so on. And described the foundation and advantages in biomedical field.

关 键 词：Fe_3O_4磁性纳米粒子 靶向给药 核磁共振成像 热疗 基因治疗 

分 类 号：R981[医药卫生—药品]